\u5728\u63a5\u53d7Survodutide\uff08BI 456906\uff09\u6cbb\u7597\u7684\u4e24\u4e2a\u6700\u9ad8\u5242\u91cf\u7ec4\u4e2d\uff0c\u9ad8\u8fbe40%\u7684\u53d7\u8bd5\u8005\u4f53\u91cd\u4e0b\u964d\u81f3\u5c1120%[1]\nSurvodutide\u5177\u6709\u65b0\u7684\u4f5c\u7528\u673a\u5236\uff08GCG\/GLP-1\u53cc\u53d7\u4f53\u6fc0\u52a8\u5242\uff09\uff0c\u5728\u964d\u4f4e\u98df\u6b32\u7684\u540c\u65f6\uff0c\u8fd8\u80fd\u76f4\u63a5\u5f71\u54cd\u809d\u810f\u7684\u80fd\u91cf\u6d88\u8017[2]\n\u8be6\u7ec6\u6570\u636e\u5df2\u57282023\u5e74\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\u7b2c83\u5c4a\u5927\u4f1a\u4e0a\u516c\u5e03
\n\u5fb7\u56fd\u6bb7\u683c\u7ff0\u548c\u4e39\u9ea6\u54e5\u672c\u54c8\u68392023\u5e746\u670825\u65e5 \/\u7f8e\u901a\u793e\/ — \u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548cZealand Pharma\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aZEAL\uff09\u4eca\u5929\u516c\u5e03\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u5728\u63a5\u53d746\u5468\u6cbb\u7597\u3001\u4e0d\u4f34\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\uff0cSurvodutide\uff08\u53c8\u79f0\u4e3aBI 456906\uff09\u7684\u7597\u6548\u4f18\u4e8e\u5b89\u6170\u5242\u3002[1]\u4e0a\u8ff0\u53d1\u73b0\u5df2\u5728\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u5723\u5730\u4e9a\u54e5\u4e3e\u884c\u76842023\u5e74\u7f8e\u56fd\u7cd6\u5c3f\u75c5\u534f\u4f1a\u7b2c83\u5c4a\u5927\u4f1a\u4e0a\u516c\u5e03\u3002<\/p>\n
II\u671f\u7814\u7a76\u5305\u62ec\u4e24\u9879\u5206\u6790\uff1a\u8ba1\u5212\u6cbb\u7597\u5206\u6790\uff08\u968f\u673a\u5206\u7ec4\u65f6\u5206\u914d\u7684\u5242\u91cf\uff0c\u4e5f\u662f\u4e3b\u8981\u7ec8\u70b9\uff09\u548c\u5b9e\u9645\u6cbb\u7597\u5206\u6790\uff08\u6cbb\u7597\u7ed3\u675f\u65f6\u7684\u5242\u91cf\uff09\u3002[1]\u5b8c\u6210\u7814\u7a76\u76844.8 mg\u5242\u91cf\u7ec4\u53d7\u8bd5\u8005\uff08\u5b9e\u9645\u6cbb\u7597\u5206\u6790\uff09\u4f53\u91cd\u4e0b\u964d\u63a5\u8fd119%\u3002[1]\u5982\u524d\u516c\u5e03\uff0c\u8ba1\u5212\u6cbb\u7597\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u968f\u673a\u5206\u7ec4\u81f34.8 mg\u5242\u91cf\u7ec4\u7684\u6240\u6709\u53d7\u8bd5\u8005\u4f53\u91cd\u4e0b\u964d\u63a5\u8fd115%\u3002[1]Survodutide\u6cbb\u7597\u7ec4\u53d7\u8bd5\u8005\u7684\u4f53\u91cd\u4e0b\u964d\u8d8b\u52bf\u5e76\u672a\u5728\u7b2c46\u5468\u8fdb\u5165\u5e73\u53f0\u671f\uff0c\u63d0\u793a\u5982\u5ef6\u957f\u6cbb\u7597\u671f\uff0c\u53d7\u8bd5\u8005\u4f53\u91cd\u53ef\u8fdb\u4e00\u6b65\u4e0b\u964d\u3002[1]\n
“\u9274\u4e8e\u80a5\u80d6\u53ca\u5176\u8bf8\u591a\u76f8\u5173\u5e76\u53d1\u75c7\u7684\u9ad8\u60a3\u75c5\u7387\uff0c\u8feb\u5207\u9700\u8981\u7814\u53d1\u80fd\u591f\u6709\u6548\u6cbb\u7597\u80a5\u80d6\u7684\u65b9\u6cd5\uff0c”\u7231\u5c14\u5170\u90fd\u67cf\u6797\u5927\u5b66\u6559\u6388\u3001\u8bd5\u9a8c\u4e3b\u8981\u7814\u7a76\u8005Carel le Roux\u535a\u58eb\u8868\u793a\uff0c”\u5f53\u524d\u7684\u80a5\u80d6\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u805a\u7126\u4e8e\u901a\u8fc7\u51cf\u5c11\u80fd\u91cf\u6444\u5165\u6765\u51cf\u8f7b\u4f53\u91cd\u3002[2]Survodutide\u80fd\u591f\u540c\u65f6\u6fc0\u6d3b\u80f0\u9ad8\u8840\u7cd6\u7d20\u548cGLP-1\u53d7\u4f53\uff0c\u5728\u6291\u5236\u98df\u6b32\u7684\u540c\u65f6\uff0c\u8fd8\u80fd\u63d0\u9ad8\u80fd\u91cf\u6d88\u8017\uff0c\u4ece\u800c\u6cbb\u7597\u80a5\u80d6\u3002[2]2\u671f\u6570\u636e\u4ee4\u4eba\u632f\u594b\uff0c\u8bc1\u660e\u6709\u5fc5\u8981\u9488\u5bf9Survodutide\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u7684III\u671f\u8bd5\u9a8c\u3002”<\/p>\n
46\u5468\u6cbb\u7597\u671f\u7ed3\u675f\u540e\uff0c\u5728\u63a5\u53d7Survodutide\u6cbb\u7597\u7684\u4e24\u4e2a\u6700\u9ad8\u5242\u91cf\u7ec4\u4e2d\uff0c\u9ad8\u8fbe40%\u7684\u53d7\u8bd5\u8005\u4f53\u91cd\u4e0b\u964d\u81f3\u5c1120%\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e2d\u8fd9\u4e00\u6bd4\u4f8b\u4e3a0%\u3002[1]\u5728survodutide 4.8 mg\u5242\u91cf\u7ec4\u4e2d\uff0c\u4f53\u91cd\u4e0b\u964d15%\u6216\u66f4\u591a\u7684\u53d7\u8bd5\u8005\u6bd4\u4f8b\u4e3a67%\uff0c\u800c\u5728\u5b89\u6170\u5242\u7ec4\u4e2d\uff0c\u8fd9\u4e00\u6bd4\u4f8b\u4e3a4.3%\u3002[1]\n
\u63a5\u53d7survodutide\u6cbb\u7597\u7684\u53d7\u8bd5\u8005\u672a\u51fa\u73b0\u975e\u9884\u671f\u5b89\u5168\u6027\u6216\u8010\u53d7\u6027\u95ee\u9898\u3002Survodutide\u6cbb\u7597\u7ec4\u4e2d\uff0c4.2%\u7684\u53d7\u8bd5\u8005\u62a5\u544a\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u800c\u5728\u5b89\u6170\u5242\u7ec4\u4e2d\uff0c\u8fd9\u4e00\u6bd4\u4f8b\u4e3a6.5%\u3002[1]\u4e24\u7ec4\u53d7\u8bd5\u8005\u4e2d\uff0c\u5206\u522b\u670924.6%\u548c3.9%\u7684\u53d7\u8bd5\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u7ec8\u6b62\u6cbb\u7597\uff0c\u4e3b\u8981\u662f\u5242\u91cf\u9012\u589e\u671f\u53d1\u751f\u7684\u80c3\u80a0\u9053\u4e0d\u826f\u4e8b\u4ef6\u3002[1]\u591a\u6570\u6cbb\u7597\u7ec8\u6b62\u7531\u5242\u91cf\u5feb\u901f\u9012\u589e\u671f\u53d1\u751f\u7684\u4e0d\u826f\u4e8b\u4ef6\u5f15\u8d77\u3002\u5982\u5242\u91cf\u9012\u589e\u901f\u5ea6\u66f4\u4e3a\u548c\u7f13\uff0c\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u6b21\u6570\u53ef\u80fd\u4f1a\u4e0b\u964d\u3002[1]\u7814\u7a76\u62a5\u544a\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e0eGLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u8fd9\u7c7b\u836f\u7269\u7684\u9884\u671f\u4e0d\u826f\u4e8b\u4ef6\u76f8\u4f3c\u3002[1]\n
“\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u957f\u671f\u81f4\u529b\u4e8e\u5fc3\u8840\u7ba1\u3001\u80be\u75c5\u3001\u4ee3\u8c22\u75be\u75c5\u65b0\u7597\u6cd5\u7684\u7814\u53d1\u3002II\u671f\u8bd5\u9a8c\u8be6\u5b9e\u548c\u4ee4\u4eba\u4fe1\u670d\u7684\u6570\u636e\uff0c\u4ee4\u4eba\u5907\u53d7\u9f13\u821e\uff0c”\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u4eba\u7528\u836f\u54c1\u4e1a\u52a1\u8d1f\u8d23\u4ebaCarinne Brouillon\u8868\u793a\uff0c”\u5728\u964d\u4f4e\u98df\u6b32\u7684\u540c\u65f6\uff0cSurvodutide\u8fd8\u80fd\u901a\u8fc7\u809d\u810f\u4ee3\u8c22\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u3002\u6211\u4eec\u671f\u5f85\u4e0e\u533b\u7597\u76d1\u7ba1\u90e8\u95e8\u5f00\u5c55\u8fdb\u4e00\u6b65\u6c9f\u901a\uff0c\u5c3d\u65e9\u542f\u52a8\u8be5\u53cc\u53d7\u4f53\u6fc0\u52a8\u5242\u7684III\u671f\u8bd5\u9a8c\uff0c\u4ee5\u586b\u8865\u8fd9\u4e00\u75be\u75c5\u9886\u57df\u7684\u6cbb\u7597\u7f3a\u53e3\u3002”<\/p>\n
“\u80a5\u80d6\u662f\u5f53\u4eca\u533b\u5b66\u754c\u6700\u4e3a\u91cd\u5927\u7684\u533b\u7597\u4fdd\u5065\u6311\u6218\u4e4b\u4e00\uff0c”Zealand Pharma\u9996\u5e2d\u533b\u5b66\u5b98David Kendall\u533b\u5b66\u535a\u58eb\u8868\u793a\uff0c”Zealand Pharma\u62e5\u6709\u53d1\u73b0\u548c\u5f00\u53d1\u9776\u5411\u5173\u952e\u4ee3\u8c22\u9014\u5f84\u7684\u591a\u80bd\u7c7b\u836f\u7269\u7684\u7ecf\u9a8c\u548c\u6210\u529f\u6848\u4f8b\u3002\u8be5\u7c7b\u836f\u7269\u53ef\u5e2e\u52a9\u8d85\u91cd\u548c\u80a5\u80d6\u60a3\u8005\u5927\u5e45\u51cf\u8f7b\u4f53\u91cd\u548c\u6539\u5584\u8bf8\u591a\u80a5\u80d6\u76f8\u5173\u5e76\u53d1\u75c7\u3002”<\/p>\n
\u7814\u7a76\u7b80\u4ecb<\/p>\n
\u4e00\u9879\u5728\u4e0d\u4f34\u67092\u578b\u7cd6\u5c3f\u75c5\u7684\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8bd5\u8005\u4e2d\u6bd4\u8f83\u76ae\u4e0b\u7ed9\u836f46\u5468\u3001\u6bcf\u5468\u4e00\u6b21Survodutide\u548c\u5b89\u6170\u5242\u5bf9\u7167\u7684\u968f\u673a\u3001\u5e73\u884c\u5206\u7ec4\u3001\u5242\u91cf\u63a2\u7d22\u7684II\u671f\u7814\u7a76\u3002[1]\u8bd5\u9a8c\u5305\u62ec20\u5468\u7684\u5242\u91cf\u9012\u589e\u671f\u548c26\u5468\u7684\u5242\u91cf\u7ef4\u6301\u671f\uff0c\u8bc4\u4f30\u7ed9\u836f\u5242\u91cf\u5206\u522b\u4e3a0.6 mg\u30012.4 mg\u30013.6 mg\u548c4.8 mg\u7684\u7597\u6548\u3002[1]\n
Survodutide\uff08BI 456906\uff09\u7b80\u4ecb<\/p>\n
Survodutide\u662f\u4e00\u79cd\u80f0\u9ad8\u8840\u7cd6\u7d20\/GLP-1\u53d7\u4f53\u53cc\u91cd\u6fc0\u52a8\u5242\uff0c\u53ef\u540c\u65f6\u6fc0\u6d3bGLP-1\u548c\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u4f53\u3002\u8fd9\u4e24\u79cd\u53d7\u4f53\u5728\u65b0\u9648\u4ee3\u8c22\u529f\u80fd\u8c03\u63a7\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002[2]Survodutide\u7531\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548cZealand Pharma\u5171\u540c\u5f00\u53d1\uff0c\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u5728\u5fc3-\u80be-\u4ee3\u8c22\u75be\u75c5\u9886\u57df\u7814\u53d1\u4ea7\u54c1\u7ec4\u5408\u7684\u4e00\u90e8\u5206\u3002<\/p>\n
\u6211\u4eec\u540c\u65f6\u4e5f\u5728\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u548c\u809d\u7ea4\u7ef4\u5316\uff08F1\/F2\/F3\u671f\uff09\u6210\u4eba\u60a3\u8005\u4e2d\u5f00\u5c55II\u671f\u7814\u7a76\uff0c\u8bc4\u4f30Survodutide\u7684\u7597\u6548\u3002[3]\u8bd5\u9a8c\u9884\u8ba1\u57282023\u5e74\u7b2c4\u5b63\u5ea6\u5b8c\u6210\u3002Survodutide\u5df2\u83b7\u5f97\u7f8e\u56fdFDA\u9488\u5bf9\u5176\u6210\u4ebaNASH\u9002\u5e94\u75c7\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\u8ba4\u5b9a\u3002[4]\n
\u8d85\u91cd\u548c\u80a5\u80d6\u7b80\u4ecb<\/p>\n
2016\u5e74\uff0c\u5168\u7403\u8d85\u8fc719\u4ebf\u6210\u5e74\u4eba\u4f53\u91cd\u8d85\u91cd\uff0c\u8d85\u91cd\u5b9a\u4e49\u4e3a\u4f53\u91cd\u6307\u6570\uff08BMI\uff09\u8fbe\u523025\u6216\u66f4\u9ad8\u3002[5]\u5176\u4e2d\u8d85\u8fc76.5\u4ebf\u4eba\u60a3\u6709\u80a5\u80d6\uff0c\u80a5\u80d6\u5b9a\u4e49\u4e3aBMI\u8fbe\u523030\u6216\u66f4\u9ad8\u3002[6]\u4e16\u754c\u80a5\u80d6\u8054\u76df\u9884\u6d4b\uff0c2025\u5e74\u5168\u7403\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u6570\u53ef\u80fd\u8fbe\u523027\u4ebf\uff0c\u5c06\u6210\u4e3a\u5168\u7403\u6027\u5065\u5eb7\u96be\u9898\uff0c\u7ed9\u4e2a\u4eba\u3001\u533b\u7597\u4fdd\u5065\u7cfb\u7edf\u548c\u793e\u4f1a\u5c06\u5e26\u6765\u6c89\u91cd\u7684\u8d1f\u62c5\u3002[6]\u8d85\u91cd\u548c\u80a5\u80d6\u662f\u590d\u6742\u7684\u6162\u6027\u75be\u75c5\uff0c\u6d89\u53ca\u8102\u80aa\u7684\u5f02\u5e38\u6216\u8fc7\u5ea6\u84c4\u79ef\uff0c\u5bf9\u4e2a\u4eba\u6574\u4f53\u5065\u5eb7\u6784\u6210\u5a01\u80c1\u3002[7]\n
\u5173\u4e8e\u52c3\u6797\u683c\u6bb7\u683c\u7ff0<\/p>\n
\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81f4\u529b\u4e8e\u7814\u7a76\u7a81\u7834\u6027\u7597\u6cd5\uff0c\u65e8\u5728\u53d8\u9769\u751f\u547d\uff0c\u5b88\u62a4\u4e16\u4e16\u4ee3\u4ee3\u7684\u5065\u5eb7\u3002\u4f5c\u4e3a\u4e00\u5bb6\u7814\u53d1\u9a71\u52a8\u7684\u5168\u7403\u9886\u5148\u751f\u7269\u5236\u836f\u4f01\u4e1a\uff0c\u516c\u53f8\u5728\u533b\u7597\u9700\u6c42\u9ad8\u5ea6\u672a\u5f97\u5230\u6ee1\u8db3\u7684\u9886\u57df\u901a\u8fc7\u521b\u65b0\u5c55\u73b0\u4ef7\u503c\u3002\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u81ea1885\u5e74\u6210\u7acb\u4ee5\u6765\u4e00\u76f4\u662f\u4e00\u5bb6\u72ec\u7acb\u7684\u5bb6\u65cf\u4f01\u4e1a\uff0c\u59cb\u7ec8\u7740\u773c\u957f\u8fdc\u4e0e\u53ef\u6301\u7eed\u53d1\u5c55\u3002\u5728\u4eba\u7528\u836f\u54c1\u3001\u52a8\u7269\u4fdd\u5065\u4e24\u5927\u4e1a\u52a1\u9886\u57df\uff0c\u5168\u7403\u6709\u8d85\u8fc75.3\u4e07\u540d\u5458\u5de5\u670d\u52a1\u903e130\u4e2a\u5730\u533a\u3002\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u8bbf\u95ee\uff1awww.boehringer-ingelheim.com<\/p>\n
\u5173\u4e8eZealand Pharma A\/S<\/p>\n
Zealand Pharma A\/S\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1aZEAL\uff09\uff08\u7b80\u79f0”Zealand”\uff09\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u53d1\u73b0\u548c\u5f00\u53d1\u80bd\u7c7b\u836f\u7269\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u3002Zealand\u53d1\u660e\u768410\u4f59\u79cd\u5019\u9009\u836f\u7269\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\uff0c\u5176\u4e2d2\u79cd\u5df2\u4e0a\u5e02\uff0c3\u79cd\u5904\u4e8e\u540e\u671f\u5f00\u53d1\u9636\u6bb5\u3002\u8be5\u516c\u53f8\u4e0e\u591a\u5bb6\u5236\u836f\u516c\u53f8\u5efa\u7acb\u4e86\u5f00\u53d1\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u5e76\u4e3a\u5176\u4e0a\u5e02\u4ea7\u54c1\u5efa\u7acb\u4e86\u5546\u4e1a\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\u3002<\/p>\n
Zealand \u6210\u7acb\u4e8e 1998 \u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u4e39\u9ea6\u54e5\u672c\u54c8\u6839\uff0c\u5728\u5305\u62ec\u6ce2\u58eb\u987f\u5728\u5185\u7684\u7f8e\u56fd\u8bbe\u6709\u529e\u4e8b\u5904\u3002\u6709\u5173 Zealand \u4e1a\u52a1\u548c\u6d3b\u52a8\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee www.zealandpharma.com<\/p>\n
\u53c2\u8003\u6587\u732e<\/p>\n
1 le Roux CW et al. A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study of BI 456906 in People with Overweight\/Obesity. Presented at the American Diabetes Association’s 83rd Scientific Sessions 2023; 23 June 2023. 51-OR.<\/p>\n
2 T. Zimmerman et al. BI 456906: Discovery and preclinical pharmacology of a novel GCGR\/GLP-1R dual agonist with robust anti-obesity efficacy. Molecular Metabolism. 2022;66:101633.<\/p>\n
3 ClinicalTrials.gov. A Study to Test Safety and Efficacy of BI456906 in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3). Available at https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04771273. Accessed June 2023.<\/p>\n
4 Boehringer Ingelheim and Zealand Pharma Receive FDA Fast Track Designation for Investigational Treatment for NASH. Available at https:\/\/www.boehringer-ingelheim.com\/us\/press-release\/boehringer-ingelheim-and-zealand-pharma-receive-fda-fast-track-designation.Accessed June 2023.<\/p>\n
5 World Health Organization. Obesity and Overweight. Available at https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight. Accessed June 2023.<\/p>\n
6 World Heart Federation. Obesity. 2015. Available at: https:\/\/world-heart-federation.org\/what-we-do\/obesity\/#:~:text=Global%20estimates%20suggest%20that%20almost,overweight%20or%20obesity%20by%202025. Accessed June 2023.<\/p>\n
7 Bray GA et al. Obesity: A chronic relapsing progressive disease process. A position statement of the World Obesity Federation. Obes Rev 2017;18:715\u2013723.<\/p>\n","protected":false},"excerpt":{"rendered":"
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