{"id":8019,"date":"2023-06-10T08:29:42","date_gmt":"2023-06-10T00:29:42","guid":{"rendered":"http:\/\/zhonghua.gshlw.com\/?p=8019"},"modified":"2023-06-10T08:29:42","modified_gmt":"2023-06-10T00:29:42","slug":"torchlight%e7%a0%94%e7%a9%b6%ef%bc%9a%e5%85%a8%e7%90%83%e9%a6%96%e5%8f%91%ef%bc%8c%e7%96%be%e7%97%85%e8%bf%9b%e5%b1%95%e6%88%96%e6%ad%bb%e4%ba%a1%e9%a3%8e%e9%99%a9%e9%99%8d%e4%bd%8e35","status":"publish","type":"post","link":"http:\/\/zhonghua.gshlw.com\/zixun\/8019.html","title":{"rendered":"TORCHLIGHT\u7814\u7a76\uff1a\u5168\u7403\u9996\u53d1\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e35"},"content":{"rendered":"<p><strong>TORCHLIGHT\u7814\u7a76\uff1a\u5168\u7403\u9996\u53d1\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e35<\/strong>%<\/p>\n<p>\u7531\u89e3\u653e\u519b\u603b\u533b\u9662\u80bf\u7624\u533b\u5b66\u90e8\u6c5f\u6cfd\u98de\u6559\u6388\u7275\u5934\u5f00\u5c55\u7684\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\uff08nab-P\uff09\u6cbb\u7597\u9996\u8bcaIV\u671f\u6216\u590d\u53d1\u8f6c\u79fb\u6027\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7684III\u671f\u7814\u7a76\uff08TORCHLIGHT\uff09\u6210\u679c\u4ee5\u91cd\u78c5\u7814\u7a76\u6458\u8981\uff08LBA\uff09\u5f62\u5f0f\u5728ASCO\u5e74\u4f1a\u7684\u5feb\u901f\u6458\u8981\u4e13\u573a\u4e0a\u9996\u6b21\u53d1\u5e03\uff0c\u4e2d\u5c71\u5927\u5b66\u5b59\u9038\u4ed9\u7eaa\u5ff5\u533b\u9662\u5218\u5f3a\u6559\u6388\u5bf9\u7814\u7a76\u8be6\u7ec6\u7ed3\u679c\u8fdb\u884c\u4e86\u53e3\u5934\u62a5\u544a\u3002<\/p>\n<p>TORCHLIGHT\u7814\u7a76\uff08NCT04085276\uff09\u662f\u4e00\u9879\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u7eb3\u5165531\u4f8b\u9996\u8bcaIV\u671f\u6216\u590d\u53d1\u8f6c\u79fb\u6027TNBC\u60a3\u8005\uff0c\u662f\u56fd\u5185\u9996\u4e2a\u5728\u665a\u671fTNBC\u514d\u75ab\u6cbb\u7597\u9886\u57df\u53d6\u5f97\u9633\u6027\u7ed3\u679c\u7684III\u671f\u6ce8\u518c\u7814\u7a76\u3002<\/p>\n<p>\u622a\u81f32022\u5e7411\u670830\u65e5\uff08\u4e2d\u4f4d\u968f\u8bbf14\u4e2a\u6708\uff09\uff0cTORCHLIGHT\u671f\u4e2d\u5206\u6790\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n<p>\u4e0e\u5355\u7eaf\u5316\u7597\uff08nab-P\uff09\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408nab-P\u7528\u4e8e\u9996\u8bcaIV\u671f\u6216\u590d\u53d1\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u53ef\u663e\u8457\u5ef6\u957fPD-L1\u9633\u6027\u4eba\u7fa4\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e35%\u3002\u76f2\u6001\u72ec\u7acb\u4e2d\u5fc3\u8bc4\u5ba1\u59d4\u5458\u4f1a\uff08BICR\uff09\u8bc4\u4f30\u7684\u4e2d\u4f4dPFS\u5206\u522b\u4e3a8.4 vs 5.6\u4e2a\u6708\uff0cHR=0.65\uff0895%CI 0.47-0.91\uff09\uff0c\u53cc\u4fa7P=0.0102\u3002<br \/>\n\u5728PD-L1\u9633\u6027\u548c\u610f\u5411\u6027\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u4e2d\uff0c\u5747\u89c2\u5bdf\u5230\u7279\u745e\u666e\u5229\u5355\u6297\u8054\u5408nab-P\u7ec4\u6709\u660e\u663e\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u83b7\u76ca\u8d8b\u52bf\u3002\u5176\u4e2d\uff0cPD-L1\u9633\u6027\u4eba\u7fa4\u7684\u4e24\u7ec4\u4e2d\u4f4dOS\u5206\u522b\u4e3a32.8 vs 19.5\u4e2a\u6708\uff08HR=0.62, 95%CI: 0.41-0.91\uff09\uff0cITT\u4eba\u7fa4\u7684\u4e24\u7ec4\u4e2d\u4f4dOS\u5206\u522b\u4e3a33.1 vs 23.5\u4e2a\u6708\uff08HR=0.69, 95%CI: 0.51-0.93\uff09\u3002<br 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