{"id":7432,"date":"2023-05-23T08:16:37","date_gmt":"2023-05-23T00:16:37","guid":{"rendered":"http:\/\/zhonghua.gshlw.com\/?p=7432"},"modified":"2023-05-23T08:16:37","modified_gmt":"2023-05-23T00:16:37","slug":"2023%e8%be%89%e7%91%9e%e9%a6%96%e5%b1%8a%e7%9a%ae%e7%a7%91%e9%ab%98%e5%b3%b0%e8%ae%ba%e5%9d%9b%e5%9c%a8%e4%ba%ac%e4%b8%be%e8%a1%8c","status":"publish","type":"post","link":"http:\/\/zhonghua.gshlw.com\/zixun\/7432.html","title":{"rendered":"2023\u8f89\u745e\u9996\u5c4a\u76ae\u79d1\u9ad8\u5cf0\u8bba\u575b\u5728\u4eac\u4e3e\u884c"},"content":{"rendered":"

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JAK\u6291\u5236\u5242\u5e26\u6765\u521b\u65b0\u7a81\u7834\uff0c\u4ee5\u79d1\u5b66\u52a9\u529b\u60a3\u8005”\u7115\u7136\u65b0\u751f”<\/p>\n

\u63a7\u5236\u7619\u75d2\u548c\u6e05\u9664\u76ae\u635f\u662fAD\u60a3\u8005\u7684\u6700\u8feb\u5207\u6cbb\u7597\u9700\u6c42[2]\uff0c\u9891\u7e41\u3001\u6301\u7eed\u548c\u5f3a\u70c8\u7684\u7619\u75d2\u8ba9\u60a3\u8005\u82e6\u4e0d\u582a\u8a00\u3002\u300a\u4e2d\u56fd\u7279\u5e94\u6027\u76ae\u708e\u60a3\u8005\u751f\u5b58\u72b6\u51b5\u8c03\u7814\u62a5\u544a\u300b\u663e\u793a\uff0c\u8fd1\u516b\u6210\u6210\u4ebaAD\u60a3\u8005\u4f34\u6709\u4e2d\u5ea6\u4ee5\u4e0a\u7619\u75d2\uff0c38.3%\u7684\u60a3\u8005\u6bcf\u5929\u8d85\u8fc710\u6b21\u7684\u7619\u75d2\u9891\u7387\uff0c57%\u7684\u60a3\u8005\u6bcf\u5929\u7619\u75d2\u6301\u7eed\u65f6\u95f4\u8d85\u8fc76\u5c0f\u65f6\uff0c\u591a\u6570\u60a3\u8005\u56e0\u7619\u75d2\u800c\u7761\u7720\u56f0\u96be\uff0c\u51cf\u5c11\u7619\u75d2\u75c7\u72b6\u662f75.8%\u7684\u4e2d\u91cd\u5ea6\u60a3\u8005\u7684\u8feb\u5207\u9700\u6c42\u3002\u7136\u800c\uff0c\u4f20\u7edf\u7cfb\u7edf\u6cbb\u7597\u65b9\u6848\u5bf9\u4e2d\u91cd\u5ea6AD\u60a3\u8005\u63a7\u5236\u4e0d\u4f73\uff0c\u8d85\u8fc775%\u7684\u533b\u751f\u5bf9\u73b0\u6709\u6cbb\u7597\u65b9\u6848\u4e0d\u6ee1\u610f[3]\uff0c\u4e34\u5e8a\u4e9f\u9700\u66f4\u591a\u521b\u65b0\u7597\u6cd5\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\u3002<\/p>\n

“\u76ae\u80a4\u5c4f\u969c\u529f\u80fd\u5f02\u5e38\u548c\u514d\u75ab\u529f\u80fd\u969c\u788d\u662fAD\u53d1\u75c5\u7684\u6838\u5fc3\u673a\u5236\uff0c\u5728\u5176\u76f8\u4e92\u4f5c\u7528\u4e0b\uff0cAD\u60a3\u8005\u5f62\u6210\u2018\u7619\u75d2-\u6414\u6293’\u7684\u6076\u6027\u5faa\u73af\uff0c\u8fdb\u4e00\u6b65\u52a0\u91cd\u76ae\u80a4\u5c4f\u969c\u635f\u4f24\u3002”\u6606\u660e\u533b\u79d1\u5927\u5b66\u7b2c\u4e00\u9644\u5c5e\u533b\u9662\u4f55\u9ece\u6559\u6388\u89e3\u91ca\u8bf4\uff1a”AD\u7684\u957f\u671f\u7ba1\u7406\u5e94\u9075\u5faa\u5065\u5eb7\u6559\u80b2\u3001\u2018\u9636\u68af\u5f0f’\u5206\u7ea7\u6cbb\u7597\u3001\u7ef4\u62a4\u76ae\u80a4\u5c4f\u969c\uff0c\u4ee5\u8fbe\u5230\u957f\u671f\u6e05\u9664\u76ae\u635f\u3001\u7f13\u89e3\u75c7\u72b6\u3001\u63d0\u9ad8\u751f\u6d3b\u8d28\u91cf\u7684\u76ee\u7684\u3002”<\/p>\n

\u968f\u7740\u79d1\u5b66\u7684\u8fdb\u6b65\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0JAK-STAT\u901a\u8def\u5728\u8c03\u8282AD\u514d\u75ab\u53d1\u75c5\u673a\u5236\u4e2d\u7684\u591a\u4e2a\u514d\u75ab\u8f74\u4e2d\u53d1\u6325\u6838\u5fc3\u4f5c\u7528\uff0c\u53c2\u4e0e\u76ae\u80a4\u5c4f\u969c\u529f\u80fd\u7684\u53d1\u751f\uff0c\u5e76\u5f71\u54cdAD\u708e\u75c7\u8fdb\u5c55\u7684\u591a\u4e2a\u73af\u8282\u3002\u4f5c\u4e3aJAK\u6291\u5236\u7814\u53d1\u9886\u57df\u5f15\u9886\u8005\uff0c \u8f89\u745e\u4ea7\u54c1\u7ec4\u5408\u53ca\u5408\u4f5c\u7814\u53d1\u8d1f\u8d23\u4eba\uff0c\u6267\u884c\u603b\u76d1Martin David\u4ecb\u7ecd\u4e86JAK\u6291\u5236\u5242\u7684\u53d1\u5c55\u5386\u7a0b\uff1a1993\u5e74\u8f89\u745e\u79d1\u5b66\u5bb6\u9996\u6b21\u786e\u8ba4JAKs\u6fc0\u9176\u662f\u591a\u79cd\u75be\u75c5\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\uff0c\u5e76\u5f00\u5c55\u4e86\u591a\u4e2a\u9776\u70b9\u7814\u7a76\u3002\u5728AD\u9886\u57df\uff0c\u4e3a\u4e86\u83b7\u5f97\u66f4\u597d\u5730\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u8f89\u745e\u7ed3\u6784\u5316\u5b66\u5bb6\u8bbe\u8ba1\u4e86\u5c0f\u5206\u5b50\u53e3\u670d\u9ad8\u9009\u62e9\u6027JAK1\u6291\u5236\u5242\u963f\u5e03\u6614\u66ff\u5c3c\uff0c\u901a\u8fc7\u963b\u65ad\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u7ed3\u5408\u4f4d\u70b9\u53ef\u9006\u6027\u548c\u9009\u62e9\u6027\u6291\u5236JAK1\uff0c\u5728\u6291\u5236AD\u81f4\u75c5\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u4f20\u5bfc\u7684\u540c\u65f6\u964d\u4f4e\u5bf9\u65e0\u5173\u7ec6\u80de\u56e0\u5b50\u7684\u5f71\u54cd\uff0c\u4ece\u800c\u907f\u514d\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n

\u590d\u65e6\u5927\u5b66\u9644\u5c5e\u4e2d\u5c71\u533b\u9662\u5415\u8fc1\u6d32\u6559\u6388\u4ece\u836f\u7269\u5b89\u5168\u6027\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\u7b49\u89d2\u5ea6\u5206\u4eabJAK\u6291\u5236\u5242\u7684\u5e94\u7528\u60c5\u51b5\uff0c\u5f3a\u8c03JAK1\u6291\u5236\u5242\u7684\u4f7f\u7528\u9700\u8981\u591a\u5b66\u79d1\u957f\u671f\u7ba1\u7406\u3002\u5415\u6559\u6388\u6307\u51fa\uff1a”\u4e2d\u91cd\u5ea6AD\u60a3\u8005\u6cbb\u7597\u524d\u548c\u6cbb\u7597\u540e\u9700\u8fdb\u884c\u89c4\u8303\u5316\u7684\u75be\u75c5\u8bc4\u4f30\uff0c\u5173\u6ce8\u836f\u7269\u7684\u6cbb\u7597\u7597\u6548\u3001\u4e0d\u826f\u53cd\u5e94\u3001\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u5b89\u5168\u6027\u53ca\u836f\u7269\u7684\u7ecf\u6d4e\u6027\u3002\u5bf9\u4e8eAD\u75c5\u4eba\u7684\u6cbb\u7597\u8fdb\u884c\u5168\u7a0b\u5316\u7684\u7ba1\u7406\u662f\u975e\u5e38\u5fc5\u8981\u7684\u3002”<\/p>\n

\u6b64\u5916\uff0c\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u4ec1\u6d4e\u533b\u9662\u53f6\u971c\u6559\u6388\u5206\u4eab\u4e86JAK\u6291\u5236\u5242\u5728\u98ce\u6e7f\u6cbb\u7597\u9886\u57df\u7684\u5e94\u7528\u60c5\u51b5\uff0c\u6307\u51faJAK\u6291\u5236\u5242\u6700\u65e9\u5728\u4e34\u5e8a\u5e94\u7528\u5728\u98ce\u6e7f\u6cbb\u7597\u9886\u57df\uff0c\u591a\u5e74\u6765\u5bf9\u4e0d\u540c\u6cbb\u7597\u80cc\u666f\u7684\u8bb8\u591a\u60a3\u8005\u5e26\u6765\u826f\u597d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\uff0c\u56e0\u6b64\u591a\u56fd\u5c06JAK\u6291\u5236\u5242\u7eb3\u5165\u4e34\u5e8a\u6307\u5357\u3002<\/p>\n

\u591a\u65b9\u63a8\u52a8\uff0c\u5168\u9762\u6784\u5efaAD\u6807\u51c6\u5316\u8bca\u7597\u65b0\u65f6\u4ee3<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u751f\u7269\u5236\u5242\u3001\u5c0f\u5206\u5b50\u9776\u5411\u6291\u5236\u5242\u7b49\u521b\u65b0\u836f\u7269\u7684\u6d8c\u73b0\uff0c\u8fbe\u6807\u6cbb\u7597\uff08treat to target\uff0cT2T\uff09\u5c06\u66f4\u597d\u5730\u63a8\u52a8AD\u7684\u89c4\u8303\u8bca\u7597\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u79d1\u5b66\u89c4\u8303\u7684\u6cbb\u7597\u65b9\u6848\u3002T2T\u4ee5\u60a3\u8005\u9700\u6c42\u4e3a\u6838\u5fc3\uff0c\u5e2e\u52a9AD\u60a3\u8005\u901a\u8fc7\u75be\u75c5\u7ba1\u7406\uff0c\u80fd\u591f\u5f88\u597d\u5730\u63a7\u5236\u75be\u75c5\uff0c\u5373\u8fbe\u5230\u75c7\u72b6\u7f13\u89e3\u3001\u76ae\u635f\u6e05\u9664\u3001\u751f\u6d3b\u8d28\u91cf\u6539\u5584\u548c\u75be\u75c5\u957f\u671f\u63a7\u5236\u7684\u76ee\u6807\u3002<\/p>\n

“\u2018\u5341\u56db\u4e94\u89c4\u5212’\u63d0\u51fa\u63a8\u52a8\u5404\u7ea7\u533b\u5b66\u5b66\u79d1\u9ad8\u8d28\u91cf\u53d1\u5c55\u4e3aAD\u4e13\u79d1\u5efa\u8bbe\u63d0\u4f9b\u5951\u673a\uff0c\u65b0\u7684\u6cbb\u7597\u7406\u5ff5\u548c\u6cbb\u7597\u65b9\u5f0f\uff0c\u4ee5\u53ca\u6570\u5b57\u5316\u53d1\u5c55\uff0c\u4e3a\u4ee5AD\u4e3a\u4ee3\u8868\u7684\u76ae\u80a4\u4e13\u75c5\u5efa\u8bbe\u548c\u5b66\u79d1\u521b\u65b0\u53d1\u5c55\u63d0\u4f9b\u4e86\u673a\u9047\u3002”\u897f\u5b89\u4ea4\u901a\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662\u803f\u677e\u6885\u6559\u6388\u8868\u793a\uff1a”\u5f53\u524dAD\u7ba1\u7406\u65b9\u6848\u4e0e\u60a3\u8005\u4e34\u5e8a\u9700\u6c42\u5b58\u5728\u4e0d\u4e00\u81f4\u7684\u60c5\u51b5\u3002\u901a\u8fc7AD\u4e13\u79d1\u8fbe\u6807\u95e8\u8bca\u5efa\u8bbe\u7684\u5b9e\u65bd\uff0c\u63a8\u5e7f\u8fbe\u6807\u6cbb\u7597\u7406\u5ff5\uff0c\u5c06\u6781\u5927\u63d0\u5347AD\u60a3\u8005\u5168\u5468\u671f\u6cbb\u7597\u7ba1\u7406\u670d\u52a1\u6c34\u5e73\uff0c\u4e3a\u4fc3\u8fdb\u76ae\u80a4\u79d1\u53ca\u533b\u9662\u9ad8\u8d28\u91cf\u53d1\u5c55\u53d1\u6325\u66f4\u5927\u4f5c\u7528\u3002”<\/p>\n

\u513f\u7ae5AD\u89c4\u8303\u5316\u8bca\u7597\u4e5f\u662f\u6784\u5efaAD\u6807\u51c6\u5316\u6cbb\u7597\u7684\u5173\u952e\u4e00\u73af\u3002\u6e56\u5357\u7701\u513f\u7ae5\u533b\u9662\u6c64\u5efa\u840d\u6559\u6388\u4ecb\u7ecd\u4e86\u513f\u7ae5AD\u73b0\u72b6\u53ca\u533b\u751f\u548c\u60a3\u8005\u672a\u88ab\u6ee1\u8db3\u7684\u9700\u6c42\uff0c\u4ee5\u53ca\u5982\u4f55\u505a\u597d\u6807\u51c6\u5316\u7684\u957f\u671f\u7ba1\u7406\u3002\u5979\u8868\u793a\uff0c\u513f\u7ae5AD\u60a3\u8005\u4ee5\u8f7b\u4e2d\u5ea6\u4e3a\u4e3b\uff0c\u4f20\u7edf\u6cbb\u7597\u901a\u5e38\u4f7f\u7528\u5916\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u548c\u5916\u7528\u9499\u8c03\u78f7\u9178\u9176\u6291\u5236\u5242\uff0c\u4f46\u957f\u671f\u4f7f\u7528\u6216\u4e0d\u5f53\u4f7f\u7528\u53ef\u80fd\u4ea7\u751f\u8bf8\u591a\u5b89\u5168\u6027\u95ee\u9898\u3002AD\u60a3\u513f\u7684\u957f\u671f\u7ba1\u7406\u9700\u8981\u533b\u3001\u60a3\u3001\u5bb6\u5c5e\u3001\u793e\u4f1a\u7684\u5171\u540c\u52aa\u529b\u3002<\/p>\n

\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u7814\u53d1\u708e\u75c7\u514d\u75ab\u6027\u75be\u75c5JAK\u901a\u8def\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u8f89\u745e\u5728JAK\u9886\u57df\u6301\u7eed\u6295\u5165\u7814\u53d1\u3002\u8f89\u745e\u4e2d\u56fd\u533a\u708e\u75c7\u4e0e\u514d\u75ab\u4e8b\u4e1a\u90e8\u603b\u7ecf\u7406\u5218\u83c1\u5973\u58eb\u8868\u793a\uff1a”\u79c9\u627f\u2018\u79d1\u5b66\u81f4\u80dc’\u7684\u7406\u5ff5\uff0c\u8f89\u745e\u708e\u75c7\u4e0e\u514d\u75ab\u4e0d\u65ad\u7a81\u7834\u521b\u65b0\uff0c\u5df2\u6210\u4e3a\u4e2d\u56fd\u975e\u5e38\u91cd\u8981\u7684\u6218\u7565\u9886\u57df\u3002\u8f89\u745e\u59cb\u7ec8\u575a\u6301\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\uff0c\u7aed\u529b\u6ee1\u8db3\u4e2d\u56fd\u60a3\u8005\u6240\u9700\uff0c\u52a9\u529b\u4e2d\u56fd\u60a3\u8005\u5f97\u5230\u4e0e\u4e16\u754c\u540c\u6b65\u7684\u521b\u65b0\u7597\u6cd5\u3002\u76ee\u524d\uff0c\u8f89\u745e\u7684\u76ae\u80a4\u79d1\u4ea7\u54c1\u7ec4\u5408\u5168\u7a0b\u8986\u76d6\u8f7b\u3001\u4e2d\u3001\u91cd\u5ea6\u7279\u5e94\u6027\u76ae\u708e\uff0c\u6ee1\u8db3\u60a3\u8005\u5168\u75c5\u7a0b\u7684\u6cbb\u7597\u9700\u6c42\u3002\u672a\u6765\uff0c\u8f89\u745e\u5c06\u7ee7\u7eed\u52a0\u901f\u521b\u65b0\u4ea7\u54c1\u7684\u7814\u53d1\u3001\u6ce8\u518c\u548c\u4e0a\u5e02\uff0c\u63a8\u52a8AD\u8fbe\u6807\u6cbb\u7597\u89c4\u8303\u5316\u548c\u4ee5\u60a3\u8005\u4e3a\u4e2d\u5fc3\u7684\u521b\u65b0\uff0c\u5e2e\u52a9\u66f4\u591a\u4e2d\u56fdAD\u60a3\u8005\u65e9\u65e5\u5b9e\u73b0\u65e0\u75d2\u6108\u80a4\uff0c\u7115\u7136\u65b0\u751f\u7684\u7f8e\u597d\u613f\u666f\u3002”<\/p>\n

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