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\u62a5\u544a\u9898\u76ee\uff1aRIPK3: Integrating cell death and inflammatory signals<\/p>\n
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\u97e9\u7167\u4e2d\u535a\u58eb\uff0c\u9886\u8bfa\uff08\u4e0a\u6d77\uff09\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u3001CEO\u30021991\u5e74\u6bd5\u4e1a\u4e8e\u6b66\u6c49\u5927\u5b66\u75c5\u6bd2\u5b66\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u7cfb\uff0c1997\u83b7\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u533b\u5b66\u9057\u4f20\u5b66\u535a\u58eb\u5b66\u4f4d\u30022002\u5e74\u5b8c\u6210\u7f8e\u56fd\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662\u80bf\u7624\u7814\u7a76\u6240\uff08NIH\uff0c NCI\uff09\u65b0\u836f\u7814\u53d1\u535a\u58eb\u540e\u8bad\u7ec3\u540e\uff0c\u4efb\u804c\u4e8e\u80fd\u6e90\u90e8\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u751f\u7269\u90e8\uff0c\u4ece\u4e8b\u6297\u4f53\u53d1\u73b0\u4e0e\u5de5\u7a0b\u6539\u9020\u7814\u7a76\u30022004\u5e74\u4efbVanderbilt University\u533b\u5b66\u9662\u80bf\u7624\u751f\u7269\u5b66\u52a9\u7406\u6559\u6388\uff0c\u5728\u8054\u90a6\u57fa\u91d1\u7684\u652f\u6301\u4e0b\u8fdb\u884c\u8111\u80f6\u8d28\u7624\u7684\u57fa\u7840\u4e0e\u8f6c\u5316\u533b\u5b66\u7814\u7a76\u30022013\u5e74\u52a0\u5165Alexion Pharmaceuticals\u516c\u53f8\uff0c\u53c2\u4e0e\u6216\u4e3b\u5bfc\u8865\u4f53\u9776\u5411\u3001\u9488\u5bf9\u4e25\u91cd\u7f55\u89c1\u75c5\u7684\u5b64\u513f\u836f\u7814\u53d1\u30022017\u5e74\u5e95\u56de\u56fd\u8d1f\u8d23\u777f\u667a\u5316\u5b66\uff08ChemPartner\uff09\u6297\u4f53\u53d1\u73b0\u4e0e\u5de5\u7a0b\u6539\u9020\u5e73\u53f0\uff0c\u670d\u52a1\u4e8e\u56fd\u5185\u5916\u533b\u836f\u516c\u53f8\u3001\u751f\u7269\u6280\u672f\u4f01\u4e1a\u548c\u79d1\u7814\u5355\u4f4d\u30022019\u5e748\u6708\u4e8e\u4e0a\u6d77\u81ea\u7531\u8d38\u6613\u533a\u5f20\u6c5f\u836f\u8c37\u6ce8\u518c\u6210\u7acb\u9886\u8bfa\uff08\u4e0a\u6d77\uff09\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\uff0c\u5f00\u5c55\u57fa\u4e8e\u8865\u4f53\u9776\u5411\u3001\u7a7f\u8d8a\u8840\u8111\u5c4f\u969c\u7684\u5927\u5206\u5b50\u836f\u7269\u9012\u9001\u6280\u672f\u3001\u7f55\u89c1\u75c5\u5b64\u513f\u836f\u7684\u521b\u65b0\u836f\u7269\u7814\u53d1\u3002<\/p>\n
\u90dd\u745e\u680b \u535a\u58eb
\n\u6613\u6155\u5cf0\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8 \u5408\u4f19\u4eba\u3001\u7814\u53d1\u4e2d\u5fc3\u8d1f\u8d23\u4eba<\/p>\n
\u90dd\u745e\u680b\u535a\u58eb\u4f5c\u4e3a\u6613\u6155\u5cf0\u5408\u4f19\u4eba&\u7814\u53d1\u4e2d\u5fc3\u8d1f\u8d23\u4eba\uff0c\u8d1f\u8d23\u836f\u7269\u65e9\u671f\u53d1\u73b0\u3001\u975e\u4e34\u5e8a\u4ee5\u53ca\u8f6c\u5316\u533b\u5b66\u5de5\u4f5c\u3002<\/p>\n
\u90dd\u745e\u680b\u535a\u58eb\u5177\u670910\u5e74+\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5f00\u53d1\u7ecf\u9a8c\uff0c\u66fe\u5728\u5357\u4eac\u4f20\u5947\u7b49\u77e5\u540d\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u4f01\u4e1a\u4e3b\u5bfc\u591a\u4e2a\u8840\u6db2\u7624\u53ca\u5b9e\u4f53\u7624CAR-T\u9879\u76ee\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u5de5\u4f5c\uff0c\u5176\u4e2dLB2102 DLL3 CAR-T\u7597\u6cd5\u9879\u76ee\u88ab\u4ee5\u9ad8\u8fbe11\u4ebf\u7f8e\u91d1\u8bb8\u53ef\u7ed9\u8bfa\u534e\u516c\u53f8\u3002<\/p>\n
\u90dd\u745e\u680b\u535a\u58eb\u5728Hepatology\u3001JVI\u7b49\u6742\u5fd7\u53d1\u8868SCI\u8bba\u6587\u5341\u4f59\u7bc7\uff1b\u7533\u8bf7\u4e2d\u56fd\u548c\u56fd\u9645\u53d1\u660e\u4e13\u5229\u5341\u4f59\u9879\u3002\u90dd\u745e\u680b\u535a\u58eb\u6301\u6709\u6b66\u6c49\u5927\u5b66\u5fae\u751f\u7269\u5b66\u535a\u58eb\u5b66\u4f4d\u3002<\/p>\n
\u4faf\u51b0 \u535a\u58eb
\n\u5fb7\u742a\u533b\u836f\u79d1\u6280 \u65b0\u836f\u7814\u53d1\u53ca\u8f6c\u5316\u533b\u5b66\u8d1f\u8d23\u4eba<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1a\u9776\u5411”Don’t eat me”\u901a\u8def\u7684\u65b0\u836f\u5f00\u53d1<\/p>\n
\u4faf\u51b0\uff0c\u5fb7\u742a\u533b\u836f\u65b0\u836f\u7814\u53d1\u53ca\u8f6c\u5316\u533b\u5b66\u8d1f\u8d23\u4eba\uff0c\u82f1\u56fd\u5229\u5179\u5927\u5b66\u751f\u7269\u533b\u5b66\u535a\u58eb\u3002\u603b\u8d1f\u8d23\u5fb7\u742a\u533b\u836f\u5927\u5206\u5b50\u53ca\u5c0f\u5206\u5b50\u836f\u7269\u7684\u53d1\u73b0\u3001\u4e34\u5e8a\u524d\u7814\u53d1\u53ca\u8f6c\u5316\u533b\u5b66\u3002\u53d1\u8868\u9ad8\u6c34\u5e73\u7814\u7a76\u8bba\u6587\u591a\u7bc7\uff0c\u5305\u62ec\u4f5c\u4e3a\u7b2c\u4e00\u4f5c\u8005Nature\u4e3b\u520a\u53caScience\u5b50\u520a\u53d1\u8868\u7684\u7814\u7a76\u8bba\u6587\u3002\u5171\u7533\u8bf7\u4e09\u5341\u4f59\u9879\u65b0\u836f\u53d1\u660e\u4e13\u5229\uff0c\u591a\u9879\u5df2\u6388\u6743\u6216\u516c\u5f00\u3002\u4f5c\u4e3a\u53d1\u660e\u4eba\u6216\u4e3b\u8981\u8d1f\u8d23\u4eba\uff0c\u5df2\u63a8\u8fdb\u591a\u6b3eADC, \u80bf\u7624\u514d\u75ab\u5355\u3001\u53cc\u6297\uff0c\u53ca\u5c0f\u5206\u5b50\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff0c\u5176\u4e2d\u5305\u62ec\u591a\u4e2aFirst-in-class\u9776\u70b9\u3002 \u5e26\u9886\u56e2\u961f\u7814\u53d1\u4e86\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684CD24\u5355\u514b\u9686\u6297\u4f53\uff0c\u76ee\u524d\u8be5\u9879\u76ee\u6b63\u5728\u7f8e\u56fdMD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u7b49\u5b9e\u9a8c\u4e2d\u5fc3\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n
\u8d3e\u6021\u660c \u535a\u58eb
\n\u795e\u6d4e\u660c\u534e \u521b\u59cb\u4eba<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1aFrom a rational disease model to ALS therapy<\/p>\n
\u8d3e\u6021\u660c\u535a\u58eb\uff0c\u6e05\u534e\u5927\u5b66\u533b\u5b66\u9662\u957f\u8058\u6559\u6388\uff0c\u5317\u5927-\u6e05\u534e\u751f\u547d\u79d1\u5b66\u8054\u5408\u4e2d\u5fc3\uff0c\u6e05\u534e-IDG\u9ea6\u6208\u6587\u8111\u79d1\u5b66\u8054\u5408\u7814\u7a76\u9662\uff0c\u6e05\u534e\u5927\u5b66\u8111\u4e0e\u667a\u80fd\u5b9e\u9a8c\u5ba4\u7814\u7a76\u5458\u3002\u4e3b\u8981\u4ece\u4e8b\u795e\u7ecf\u5143\u5b58\u6d3b\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53d1\u75c5\u673a\u5236\u7684\u7814\u7a76\u30022006\u5e74\u5728\u4e2d\u79d1\u9662\u795e\u7ecf\u79d1\u5b66\u7814\u7a76\u6240\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\uff0c\u5e08\u4ece\u738b\u4ee5\u653f\u9662\u58eb\u30022007\u5e74\uff0c\u52a0\u5165\u7f8e\u56fd\u5c0f\u9f20\u9057\u4f20\u5723\u5730\u6770\u514b\u900a\u7814\u7a76\u6240Dr. Susan Ackerman\uff08\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u58eb\uff09\u5b9e\u9a8c\u5ba4\uff0c\u5229\u7528\u5c0f\u9f20\u9057\u4f20\u5b66\u7814\u7a76\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u53d1\u75c5\u673a\u5236\u30022012\u5e74\u83b7\u5f97\u4e86\u7f8e\u56fd\u5065\u5eb7\u7814\u7a76\u9662\u9881\u53d1\u7684\u72ec\u7acb\u79d1\u5b66\u7814\u7a76\u4eba\u5956\uff08K99\/R00, pathway to independent award\uff09\uff0c2013\u5e74\u5165\u9009\u4e2d\u56fd\u56fd\u5bb6\u4eba\u624d\u8ba1\u5212\u3002\u8d3e\u6021\u660c\u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\u91cd\u70b9\u5173\u6ce8\uff1a\uff081\uff09RNA\u4ee3\u8c22\u5f02\u5e38\u548c\u5185\u8d28\u7f51\u7a33\u6001\u5931\u8c03\u5f15\u8d77\u7684\u795e\u7ecf\u9000\u884c\u6027\u548c\u795e\u7ecf\u53d1\u80b2\u969c\u788d\u7684\u75be\u75c5\u673a\u5236\uff08Brain, 2020; Protein & Cell, 2023; Cell Research, 2023;\uff09\uff1b\uff082\uff09\u54fa\u4e73\u52a8\u7269\u8bed\u97f3\u7684\u5206\u5b50\u673a\u5236\u53ca\u5176\u5728\u795e\u7ecf\u53d1\u80b2\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\uff08Molecular Psychiatry, 2023\uff09\uff1b\uff083\uff09\u5efa\u7acb\u65b0\u7684\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u7ec6\u80de\u548c\u52a8\u7269\u6a21\u578b\uff08Brain, 2020; Nat. Commun., 2023\uff09\u3002<\/p>\n
\u674e\u6cbb\u4e2d \u535a\u58eb
\n\u62fe\u7389\u513f\u7ae5\u516c\u76ca\u57fa\u91d1\u4f1a \u764c\u75c7\u751f\u7269\u5b66\u5bb6\u3001\u79d1\u666e\u4f5c\u5bb6<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1a\u513f\u7ae5\u80bf\u7624\u548c\u836f\u7269\u5f00\u53d1<\/p>\n
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\u8fd0\u8425\u81ea\u5a92\u4f53”\u83e0\u841d\u56e0\u5b50”\uff0c\u603b\u8ba2\u9605\u8005\u8d85\u767e\u4e07\u3002\u51fa\u72485\u672c\u764c\u75c7\u79d1\u666e\u7545\u9500\u4e66\uff1a\u300a\u764c\u75c7\u2022\u771f\u76f8\uff1a\u533b\u751f\u4e5f\u5728\u8bfb\u300b\u300a\u764c\u75c7\u2022\u65b0\u77e5\uff1a\u79d1\u5b66\u7ec8\u7ed3\u6050\u614c\u300b\u300a\u764c\u75c7.\u9632\u5fa1\u300b\uff0c\u300a\u6df1\u547c\u5438\uff1a\u83e0\u841d\u89e3\u5bc6\u80ba\u764c\u300b\u300a\u5979\u8bf4\uff1a\u83e0\u841d\u89e3\u5bc6\u4e73\u817a\u764c\u300b\uff0c\u8363\u83b7\u591a\u9879\u4e2d\u56fd\u9876\u5c16\u51fa\u7248\u5927\u5956\uff0c\u5305\u62ec \u6587\u6d25\u56fe\u4e66\u5956\uff0c\u4e2d\u56fd\u79d1\u666e\u4f5c\u5bb6\u534f\u4f1a\u4f18\u79c0\u79d1\u666e\u4f5c\u54c1\u91d1\u5956\uff0c\u79d1\u6280\u90e8\u4f18\u79c0\u79d1\u666e\u4f5c\u54c1\u91d1\u5956\u7b49\u3002<\/p>\n
\u53c2\u4e0e\u4e2d\u592e\u7535\u89c6\u53f0\uff0c\u51e4\u51f0\u7535\u89c6\u53f0\uff0c\u5317\u4eac\u7535\u89c6\u53f0\u3001\u8131\u53e3\u79c0\u5927\u4f1a\u7b49\u8282\u76ee\u5f55\u5236\u3002\u300a\u4e00\u5e2d\u300b\u6f14\u8bb2”\u764c\u75c7\u7684\u771f\u76f8”\uff0c\u89c6\u9891\u70b9\u51fb\u91cf\u8d85\u8fc71\u4ebf\u3002<\/p>\n
2015\u5e74\u53d1\u8d77\u5411\u65e5\u8475\u513f\u7ae5\u516c\u76ca\u9879\u76ee\uff0c2018\u5e74\u56de\u56fd\u62c5\u4efb\u62fe\u7389\u513f\u7ae5\u516c\u76ca\u57fa\u91d1\u4f1a\u79d8\u4e66\u957f\uff0c\u805a\u7126\u4e09\u4e2a\u677f\u5757\u670d\u52a1\uff0c\u5206\u522b\u4e3a\u513f\u7ae5\u764c\u75c7\u79d1\u666e\u6559\u80b2\uff0c\u513f\u7ae5\u5b89\u5b81\u8212\u7f13\uff0c\u4ee5\u53ca\u513f\u7ae5\u80bf\u7624\u8f6c\u5316\u79d1\u7814\u3002<\/p>\n
\u5218\u5fd7\u521a \u535a\u58eb
\n\u91cd\u5e86\u667a\u7fd4\u91d1\u6cf0\u751f\u7269\u5236\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8 \u9996\u5e2d\u79d1\u5b66\u5b98<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1a\u57fa\u4e8eTCRm\u7684\u836f\u7269\u7814\u7a76\u8fdb\u5c55<\/p>\n
\u5218\u5fd7\u521a\uff0c\u4e2d\u56fd\u56fd\u7c4d\u3002\u6b66\u6c49\u5927\u5b66\u9057\u4f20\u5b66\u5b66\u58eb\uff0c\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u9057\u4f20\u5b66\u7855\u58eb\u548c\u535a\u58eb\u3002\u73b0\u4efb\u91cd\u5e86\u667a\u7fd4\u91d1\u6cf0\u751f\u7269\u5236\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8463\u4e8b\u3001\u9996\u5e2d\u79d1\u5b66\u5b98\u3002\u81ea1996\u5e74\u4e00\u76f4\u4ece\u4e8b\u65b0\u578b\u6297\u4f53\u836f\u7269\u7684\u7814\u53d1\u5de5\u4f5c\uff0c\u66fe\u5148\u540e\u5728\u519b\u4e8b\u533b\u5b66\u79d1\u5b66\u9662\u751f\u7269\u5de5\u7a0b\u7814\u7a76\u6240\u3001\u82f1\u56fdHaptogen\u516c\u53f8\u3001\u7f8e\u56fdMD Anderson cancer center\u548c\u767e\u6cf0\u751f\u7269\u836f\u4e1a\u6709\u9650\u516c\u53f8\u7b49\u7814\u7a76\u673a\u6784\u548c\u4f01\u4e1a\u5de5\u4f5c\uff0c\u4e13\u6ce8\u4e8e\u65b0\u578b\u6297\u4f53\u836f\u7269\u7684\u53d1\u73b0\u3001\u9a8c\u8bc1\u53ca\u76f8\u5173\u6280\u672f\u5e73\u53f0\u7684\u5efa\u8bbe\u548c\u4f18\u5316\u3002<\/p>\n
\u7f57\u654f \u535a\u58eb
\n\u590d\u65e6\u5927\u5b66\u751f\u7269\u533b\u5b66\u7814\u7a76\u9662 \u7814\u7a76\u5458<\/p>\n
\u590d\u65e6\u5927\u5b66\u7814\u7a76\u5458\uff0c\u957f\u671f\u81f4\u529b\u4e8e\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7814\u7a76\uff0c\u5728\u65b0\u9776\u70b9\u53d1\u73b0\u548c\u836f\u7269\u5f00\u53d1\u65b9\u9762\u8fdb\u884c\u4e86\u591a\u9879\u524d\u6cbf\u6027\u63a2\u7d22\uff0c\u5e76\u63a8\u52a8\u5176\u5411\u4e34\u5e8a\u8fdb\u884c\u8f6c\u5316\u3002\u901a\u8fc7\u4f53\u5185CRISPR\u7b5b\u9009\u53d1\u73b0\u591a\u578b\u6838\u9ad3\u6e90\u6291\u5236\u578b\u7ec6\u80de\uff08PMN-MDSCs\uff09\u7684\u529f\u80fd\u53d7\u4f53CD300ld\uff0c\u5728\u80bf\u7624\u514d\u75ab\u8c03\u63a7\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\uff1b\u5efa\u7acb\u548c\u5229\u7528\u4eba\u5168\u57fa\u56e0\u7ec4\u6c34\u5e73\u53d7\u4f53\u7b5b\u9009\u5e73\u53f0\uff0c\u9274\u5b9a\u51fa\u65b0\u51a0\u75c5\u6bd2\u4e0e\u5bbf\u4e3b\u7ec6\u80de\u4e92\u4f5c\u7684\u53d7\u4f53\u8c31\u7cfb\uff0c\u4e3a\u65b0\u7684\u819c\u86cb\u767d\u9776\u70b9\u53ca\u529f\u80fd\u6027\u914d\u4f53\u7684\u7b5b\u9009\u63d0\u4f9b\u4e86\u91cd\u8981\u6280\u672f\u5e73\u53f0\u3002\u4ee5\u901a\u8baf\u4f5c\u8005\u8eab\u4efd\u5728Nature\u3001Cell Res\u3001JITC\u7b49\u671f\u520a\u53d1\u8868\u8bba\u6587\uff0c\u83b7\u5f97\u57fa\u91d1\u59d4\u9762\u4e0a\u548c\u4e13\u9879\u8d44\u52a9\uff0c\u540e\u7eed\u5c06\u9488\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u7684\u5f62\u6210\u673a\u5236\u4e0e\u9776\u5411\u8c03\u63a7\u8fdb\u884c\u6df1\u5165\u7814\u7a76\uff0c\u9010\u6b65\u5efa\u7acb\u80bf\u7624\u5185\u591a\u79cd\u7ec6\u80de\u7684\u5206\u6ccc\u7ec4\u86cb\u767d\u4e92\u4f5c\u7f51\u7edc\uff0c\u5e76\u9488\u5bf9\u529f\u80fd\u9776\u70b9\u5f00\u53d1\u6297\u4f53\u3001\u5c0f\u5206\u5b50\u548c\u75ab\u82d7\u7b49\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u3002<\/p>\n
\u6c88\u6708\u96f7 \u535a\u58eb
\n\u767e\u5965\u8d5b\u56fe \u8463\u4e8b\u957f\u517cCEO<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1aRenNano\u548cRenTCR: \u4e0d\u65ad\u521b\u65b0\u7684\u751f\u7269\u836f\u5f00\u53d1<\/p>\n
\u6c88\u6708\u96f7\u535a\u58eb\u662f\u767e\u5965\u8d5b\u56fe\uff08\u5317\u4eac\uff09\u533b\u836f\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u7684\u8463\u4e8b\u957f\u517cCEO\u30022003\u5e74\u83b7University of Massachusetts School of Medicine \u514d\u75ab\u5b66\u535a\u58eb\u3002\u5177\u6709\u8fd130\u5e74\u7684\u514d\u75ab\u5b66\u3001\u57fa\u56e0\u7f16\u8f91\u3001\u6a21\u5f0f\u52a8\u7269\u75be\u75c5\u6a21\u578b\u5f00\u53d1\u4ee5\u53ca\u6297\u4f53\u836f\u7269\u7814\u53d1\u7ecf\u9a8c\u30022009\u5e74\u5728\u5317\u4eac\u6210\u7acb\u767e\u5965\u8d5b\u56fe\uff08Biocytogen\uff09\u3002\u8fc7\u53bb\u5341\u591a\u5e74\u95f4\uff0c\u5e26\u9886\u767e\u5965\u8d5b\u56fe\u53d1\u5c55\u6210\u4e3a\u62e5\u6709\u6db5\u76d6\u9776\u70b9\u9a8c\u8bc1\u3001\u5168\u4eba\u6297\u4f53\u836f\u7269\u89c4\u6a21\u5316\u5f00\u53d1\u3001\u4e0d\u540c\u79cd\u5c5e\u52a8\u7269\u4f53\u5185\u836f\u7406\u836f\u6548\u8bc4\u4ef7\u3001\u56fd\u5185\u5916IND\u7533\u62a5\u53ca\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5b8c\u6574\u6297\u4f53\u836f\u7269\u7814\u53d1\u4f53\u7cfb\u7684\u56fd\u9645\u6027\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u4f01\u4e1a\u81f4\u529b\u4e8e”\u6210\u4e3a\u5168\u7403\u65b0\u836f\u53d1\u6e90\u5730”\u3002<\/p>\n
\u6c64\u7eb3\u5e73 \u535a\u58eb
\n\u4e0a\u6d77\u76ca\u8bfa\u601d\u751f\u7269\u6280\u672f\u80a1\u4efd\u6709\u9650\u516c\u53f8 \u6bd2\u7406\u4e8b\u4e1a\u90e8\u9ad8\u7ea7\u526f\u603b\u7ecf\u7406\u3001\u4e0a\u6d77GLP\u673a\u6784\u8d1f\u8d23\u4eba<\/p>\n
DCST\uff0c\u7814\u7a76\u5458\uff0c\u7855\u58eb\u751f\u5bfc\u5e08<\/p>\n
16+\u5e74\u6bd2\u7406\u5b66\u7814\u7a76\u7ecf\u9a8c<\/p>\n
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\u4f0d\u7ef4\u601d \u535a\u58eb
\n\u65e0\u9521\u8bfa\u5b87\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8 \u9996\u5e2d\u6280\u672f\u5b98<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1aDevelopment of Theranostics for Metastatic Clear Cell Renal Cell Carcinoma<\/p>\n
\u4e0a\u6d77\u590d\u65e6\u5927\u5b66\u5316\u5b66\u5b66\u58eb\uff0c\u7f8e\u56fd\u7ebd\u7ea6\u77f3\u6eaa\u5dde\u7acb\u5927\u5b66\u5316\u5b66\u535a\u58eb\u3002\u73b0\u4efb\u65e0\u9521\u8bfa\u5b87\u533b\u836f\u79d1\u6280\u6709\u9650\u516c\u53f8\u9996\u5e2d\u6280\u672f\u5b98\uff0c\u66fe\u88ab\u82cf\u5dde\u5927\u5b66\u533b\u5b66\u90e8\u653e\u5c04\u533b\u5b66\u4e0e\u9632\u62a4\u5b66\u9662\u8058\u4e3a\u517c\u804c\u6559\u6388\u3002\u5386\u4efb\u7f8e\u56fd\u9ed8\u514b\u5236\u836f\u516c\u53f8\u9996\u5e2d\u79d1\u5b66\u5bb6\u3001\u7f8e\u56fd USPTO \u6ce8\u518c\u4e13\u5229\u4ee3\u7406\uff08\u4efb\u804c\u4e8e\u7f8e\u56fd\u65b0\u6cfd\u897fGearhart Law\u5f8b\u5e08\u4e8b\u52a1\u6240\uff09\u3001\u4e2d\u56fd\u51ef\u745e\u5eb7\u5b81\u751f\u7269\u5de5\u7a0b\uff08\u6b66\u6c49\uff09\u516c\u53f8\u526f\u603b\u88c1\u3001\u7c73\u5ea6\uff08\u5357\u4eac\uff09\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\u9996\u5e2d\u6280\u672f\u5b98\u7b49\u804c\u3002<\/p>\n
\u5f90\u4f1f \u535a\u58eb
\n\u5242\u6cf0\u533b\u836f CSO<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1a\u4e0b\u4e00\u4ee3mRNA\u7f16\u7801\u86cb\u767d\u514d\u75ab\u6cbb\u7597\u548c\u836f\u7269\u9012\u9001<\/p>\n
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\u6bb7\u6587\u52bc \u535a\u58eb
\n\u4e98\u559c\u751f\u7269 \u836f\u7406\u6bd2\u7406\u90e8\u9ad8\u7ea7\u603b\u76d1<\/p>\n
\u62a5\u544a\u9898\u76ee\uff1a\u88c5\u7532\u578bCAR-T\u6cbb\u7597\u5b9e\u4f53\u7624\u7684\u4e34\u5e8a\u524d\u7814\u7a76<\/p>\n
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\u5360\u4e00\u5e06 \u535a\u58eb
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\u8d75\u5b5d\u658c \u535a\u58eb
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