{"id":12499,"date":"2024-01-30T09:41:57","date_gmt":"2024-01-30T01:41:57","guid":{"rendered":"http:\/\/www.zxlzh.cn\/?p=12499"},"modified":"2024-01-30T09:41:57","modified_gmt":"2024-01-30T01:41:57","slug":"%e4%ba%9a%e8%99%b9%e5%8c%bb%e8%8d%af%e4%ba%8e2024-asco-gu%e5%85%ac%e5%b8%83%e8%86%80%e8%83%b1%e7%99%8c%e8%af%8a%e6%96%ad%e5%92%8c%e7%ae%a1%e7%90%86%e8%8d%af%e7%89%a9apl-1706-iii%e6%9c%9f%e4%b8%b4","status":"publish","type":"post","link":"http:\/\/zhonghua.gshlw.com\/zixun\/12499.html","title":{"rendered":"\u4e9a\u8679\u533b\u836f\u4e8e2024 ASCO-GU\u516c\u5e03\u8180\u80f1\u764c\u8bca\u65ad\u548c\u7ba1\u7406\u836f\u7269APL-1706 III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u548c\u771f\u5b9e\u4e16\u754c\u7814\u7a76\u6570\u636e"},"content":{"rendered":"<p>\u4e13\u6ce8\u4e8e\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7684\u5168\u7403\u5316\u521b\u65b0\u836f\u516c\u53f8\u4e9a\u8679\u533b\u836f\u8fd1\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u57282024\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7814\u8ba8\u4f1a\uff08ASCO GU\uff09\u4e0a\u4ee5\u58c1\u62a5\u7684\u5f62\u5f0f\uff0c\u516c\u5e03\u4e86\u8180\u80f1\u764c\u8bca\u65ad\u548c\u7ba1\u7406\u836f\u7269APL-1706\uff08\u901a\u7528\u540d\uff1a\u704c\u6ce8\u7528\u76d0\u9178\u6c28\u916e\u620a\u9178\u5df1\u916f\uff09 III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u548c\u771f\u5b9e\u4e16\u754c\u7814\u7a76\u6570\u636e\u3002<\/p>\n<p>\u672c\u6b21\u8bd5\u9a8c\u5171158\u4f8b\u60a3\u8005\u7eb3\u5165\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff08RCT\uff0cRandomized Controlled Trial\uff09\uff0c\u5176\u4e2d37\u4f8b\u4e3a\u8bad\u7ec3\u7ec4\u60a3\u8005\uff0c6\u4f8b\u88ab\u968f\u673a\u5206\u914d\u4e0d\u8fdb\u884cBLC\u7ec4\uff0c1\u4f8b\u9000\u51fa\u3002114\u4f8b\u60a3\u8005\u6784\u6210\u5168\u5206\u6790\u96c6\u300219\u4f8b\u60a3\u8005\u7eb3\u5165\u771f\u5b9e\u4e16\u754c\u7814\u7a76\uff08RWS\uff0cReal World Study\uff09\u3002\u5728\u786e\u8bca\u4e3aTa\u3001T1\u6216CIS\u7684\u60a3\u8005\u4e2d\uff0cRCT\u4e2d\u768442\/97\u4f8b\uff0843.3%\uff09\u548cRWS\u4e2d\u76844\/12\u4f8b\uff0833.3%\uff09\u60a3\u8005\u81f3\u5c11\u6709\u4e00\u4e2aBLC\u68c0\u51fa\u800cWLC\u672a\u68c0\u51fa\u7684\u786e\u8bca\u75c5\u7076\uff08p&lt;0.0001\uff09\u3002RCT\u768411\/114\uff089.6%\uff09CIS\u60a3\u8005\u548cRWS\u76841\/14\uff087.1%\uff09\u4f8bCIS\u60a3\u8005\u5728BLC\u4e0b\u989d\u5916\u68c0\u51fa\u4e861\u4e2a\u6216\u591a\u4e2aWLC\u672a\u53d1\u73b0\u7684CIS\u75c5\u7076\u3002RCT\u4e2dPUNLMP\u3001CIS\u3001Ta\u3001T1\u548cT2 ~ T4\u80bf\u7624\u7684BLC\u68c0\u51fa\u7387\u4e3aNA\u300194.7%\u3001100%\u300198.2%\u548c100%\uff0cWLC\u7684\u68c0\u51fa\u7387\u4e3aNA\u300142.1%\u300176.1%\u300191.2%\u548c100%\u3002\u5728RWS\u4e2d\uff0cPUNLMP\u3001CIS\u3001Ta\u3001T1\u548cT2 ~ T4\u80bf\u7624\u7684BLC\u68c0\u51fa\u7387\u4e3aNA\u3001100%\u3001100%\u3001100%;WLC\u7684\u68c0\u51fa\u7387\u5206\u522b\u4e3aNA\u300150%\u300181%\u3001100%\u548c100%; RCT\u548cRWS\u5747\u8bc1\u5b9e\u4e86APL-1706\u8054\u5408BLC\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\u5bf9\u8180\u80f1\u764c\u7684\u68c0\u51fa\u4f18\u4e8eWLC\uff0c\u5c24\u5176\u662f\u5728CIS\u4eba\u7fa4\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n<p>APL-1706\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7(NDA)\u5df2\u4e8e2023\u5e7411\u6708\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u53d7\u7406\u3002<\/p>\n<p>\u5173\u4e8e\u4e9a\u8679\u533b\u836f<\/p>\n<p>\u4e9a\u8679\u533b\u836f\uff08\u80a1\u7968\u4ee3\u7801\uff1a688176.SH\uff09\u6210\u7acb\u4e8e2010\u5e743\u6708\uff0c\u662f\u4e00\u5bb6\u4e13\u6ce8\u4e8e\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u53ca\u5176\u5b83\u91cd\u5927\u75be\u75c5\u9886\u57df\u7684\u5168\u7403\u5316\u521b\u65b0\u836f\u516c\u53f8\u3002\u79c9\u627f&#8221;\u6539\u5584\u4eba\u7c7b\u5065\u5eb7\uff0c\u8ba9\u751f\u547d\u66f4\u6709\u5c0a\u4e25&#8221;\u7684\u4f01\u4e1a\u4f7f\u547d\uff0c\u4e9a\u8679\u533b\u836f\u7acb\u5fd7\u6210\u4e3a\u5728\u4e13\u6ce8\u6cbb\u7597\u9886\u57df\u96c6\u7814\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u4e3a\u4e00\u4f53\u7684\u56fd\u9645\u9886\u5148\u5236\u836f\u4f01\u4e1a\uff0c\u4e3a\u4e2d\u56fd\u548c\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u6700\u4f73\u7684\u8bca\u7597\u4e00\u4f53\u5316\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<p>\u516c\u53f8\u575a\u6301\u4ee5\u521b\u65b0\u6280\u672f\u548c\u4ea7\u54c1\u4e3a\u6838\u5fc3\u9a71\u52a8\u529b\uff0c\u901a\u8fc7\u6253\u9020\u81ea\u6709\u7684\u7814\u53d1\u5e73\u53f0\u548c\u6838\u5fc3\u6280\u672f\uff0c\u6df1\u5165\u63a2\u7d22\u836f\u7269\u4f5c\u7528\u673a\u7406\uff0c\u9ad8\u6548\u7387\u7b5b\u9009\u8bc4\u4ef7\u5019\u9009\u836f\u7269\u3002\u901a\u8fc7\u5185\u90e8\u5b8c\u5584\u7684\u7814\u53d1\u4f53\u7cfb\u548c\u5168\u7403\u836f\u7269\u5f00\u53d1\u7ecf\u9a8c\u4e13\u957f\uff0c\u4e9a\u8679\u533b\u836f\u81f4\u529b\u4e8e\u5728\u4e13\u6ce8\u6cbb\u7597\u9886\u57df\u63a8\u51fa\u5168\u7403\u9996\u521b\uff08First-in-Class\uff09\u836f\u7269\u548c\u5176\u5b83\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6ee1\u8db3\u6cbb\u7597\u9700\u6c42\u7684\u521b\u65b0\u836f\u7269\u3002<\/p>\n<p>\u540c\u65f6\uff0c\u4e9a\u8679\u533b\u836f\u901a\u8fc7\u81ea\u4e3b\u7814\u53d1\u548c\u6218\u7565\u5408\u4f5c\uff0c\u56f4\u7ed5\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u75be\u75c5\u8fdb\u884c\u4ea7\u54c1\u7ba1\u7ebf\u7684\u6df1\u5ea6\u5e03\u5c40\uff0c\u9ad8\u5ea6\u5173\u6ce8\u8be5\u9886\u57df\u7684\u6280\u672f\u524d\u6cbf\u548c\u6cbb\u7597\u53d1\u5c55\u8d8b\u52bf\uff0c\u6d1e\u5bdf\u5e76\u6316\u6398\u672a\u88ab\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\uff0c\u524d\u77bb\u6027\u5730\u8fdb\u884c\u4ea7\u54c1\u89c4\u5212\u548c\u751f\u547d\u5468\u671f\u7ba1\u7406\uff0c\u6253\u9020\u6db5\u76d6\u75be\u75c5\u8bca\u65ad\u5230\u6cbb\u7597\u7684\u4f18\u52bf\u4ea7\u54c1\u7ec4\u5408\uff0c\u4ece\u800c\u9020\u798f\u66f4\u591a\u7684\u4e2d\u56fd\u548c\u5168\u7403\u60a3\u8005\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e13\u6ce8\u4e8e\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7684\u5168\u7403\u5316\u521b\u65b0\u836f\u516c\u53f8\u4e9a\u8679\u533b\u836f\u8fd1\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u57282024\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u7814\u8ba8\u4f1a\uff08ASCO GU\uff09\u4e0a\u4ee5\u58c1\u62a5\u7684\u5f62\u5f0f\uff0c\u516c\u5e03\u4e86\u8180\u80f1\u764c\u8bca\u65ad\u548c\u7ba1\u7406\u836f\u7269APL-1706\uff08\u901a\u7528\u540d\uff1a\u704c\u6ce8\u7528\u76d0\u9178\u6c28\u916e\u620a\u9178\u5df1\u916f\uff09 III\u671f\u4e34\u5e8a\u8bd5\u9a8c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"_links":{"self":[{"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/posts\/12499"}],"collection":[{"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/comments?post=12499"}],"version-history":[{"count":3,"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/posts\/12499\/revisions"}],"predecessor-version":[{"id":12503,"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/posts\/12499\/revisions\/12503"}],"wp:attachment":[{"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/media?parent=12499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/categories?post=12499"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zhonghua.gshlw.com\/wp-json\/wp\/v2\/tags?post=12499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}