{"id":11598,"date":"2023-12-12T09:43:51","date_gmt":"2023-12-12T01:43:51","guid":{"rendered":"http:\/\/www.zxlzh.cn\/?p=11598"},"modified":"2023-12-12T09:43:51","modified_gmt":"2023-12-12T01:43:51","slug":"%e7%ac%ac65%e5%b1%8a%e7%be%8e%e5%9b%bd%e8%a1%80%e6%b6%b2%e5%ad%a6%e4%bc%9a%e5%b9%b4%e4%bc%9a%e4%b8%8a%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e6%9b%b4%e6%96%b0%e4%ba%86%e5%be%88%e5%a4%9a%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"http:\/\/zhonghua.gshlw.com\/zixun\/11598.html","title":{"rendered":"\u7b2c65\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\u5e74\u4f1a\u4e0a\u4e9a\u76db\u533b\u836f\u66f4\u65b0\u4e86\u5f88\u591a\u6570\u636e"},"content":{"rendered":"

\u3010\u76f4\u51fb2023 ASH\u3011\u4e9a\u76db\u533b\u836f\u8010\u7acb\u514b\u00ae\u6d77\u5916\u7814\u7a76\u6570\u636e\u66f4\u65b0\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u5728ponatinib\u6216asciminib\u8010\u836f\u60a3\u8005\u4e2d\u7597\u6548\u663e\u8457<\/p>\n

\u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a\u2014\u2014\u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u529e\u7684\u7b2c65\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a<\/strong>\uff0c\u4ee5\u58c1\u62a5\u5c55\u793a\u5f62\u5f0f\u66f4\u65b0\u4e86\u516c\u53f8\u539f\u521b1\u7c7b\u65b0\u836f\u5965\u96f7\u5df4\u66ff\u5c3c\uff08\u7814\u53d1\u4ee3\u53f7\uff1aHQP1351\uff1b\u5546\u54c1\u540d\uff1a\u8010\u7acb\u514b\u00ae\uff09\u6cbb\u7597\u96be\u6cbb\u6027\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u7684\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6570\u636e\u3002<\/p>\n

ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684”\u4e2d\u56fd\u58f0\u97f3”\uff0c\u4eca\u5e74\u4e9a\u76db\u533b\u836f\u7684\u6838\u5fc3\u54c1\u79cd\uff08\u8010\u7acb\u514b\u00ae\u3001APG-2575\uff09\u6709\u591a\u9879\u7814\u7a76\u5165\u9009\uff0c\u5176\u4e2d\u8010\u7acb\u514b\u00ae\u83b72\u9879\u53e3\u5934\u62a5\u544a\uff0c\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fd9\u4e5f\u662f\u8010\u7acb\u514b\u00ae\u7684\u4e34\u5e8a\u8fdb\u5c55\u8fde\u7eed\u7b2c\u516d\u5e74\u5165\u9009ASH\u5e74\u4f1a\u53e3\u5934\u62a5\u544a\u3002<\/p>\n

\u7ee7\u53bb\u5e74\u5728ASH\u5e74\u4f1a\u4e0a\u53e3\u5934\u62a5\u544a\u8010\u7acb\u514b\u00ae\u6d77\u5916\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e\u540e\uff0c\u4eca\u5e74\u66f4\u65b0\u7684\u8fdb\u5c55\u901a\u8fc7\u66f4\u5927\u6837\u672c\u91cf\u60a3\u8005\u7684\u6570\u636e\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\u5728\u524d\u671f\u7ecf\u6df1\u5ea6\u6cbb\u7597\u7684CML\u6216Ph+ ALL\u60a3\u8005\u4e2d\u7597\u6548\u4e0e\u8010\u53d7\u6027\u4ff1\u4f73\uff0c\u5c24\u5176\u662f\u5728\u7ecf\u7b2c\u4e09\u4ee3TKI ponatinib\u6216\u53d8\u6784\u6291\u5236\u5242asciminib\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2d\u7597\u6548\u663e\u8457\uff0c\u8fdb\u4e00\u6b65\u63d0\u793a\u8be5\u54c1\u79cd\u6709\u671b\u4e3a\u5168\u7403CML\u6216Ph+ ALL\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\u3001MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff08MD Anderson Cancer Center\uff09\u767d\u8840\u75c5\u79d1\u7684Elias Jabbour \u6559\u6388\u8868\u793a\uff1a “HQP1351CU101\u7814\u7a76\u6b64\u6b21\u66f4\u65b0\u7684\u6570\u636e\u518d\u6b21\u663e\u793a\u4e86\u8010\u7acb\u514b\u00ae\u5353\u8d8a\u7684\u7597\u6548\uff0c\u5c24\u5176\u662f\u9488\u5bf9ponatinib\u6216asciminib\u8010\u836f\u7684\u60a3\u8005\u3002\u6211\u60f3\u8010\u7acb\u514b\u00ae\u5c06\u4e3aCML\u548cPh+ ALL\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u5168\u65b0\u6709\u6548\u7684\u6cbb\u7597\u9009\u62e9\u3002”<\/p>\n

“\u6b64\u6b21\u5728ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u8010\u7acb\u514b\u00ae\u6d77\u5916\u7814\u7a76\u6700\u65b0\u6570\u636e\u5728\u53bb\u5e74\u7684\u57fa\u7840\u4e0a\u9a8c\u8bc1\u4e86\u8be5\u54c1\u79cd\u5728ponatinib\u548casciminib\u8010\u836f\u60a3\u8005\u4e2d\u7684\u5de8\u5927\u6f5c\u529b\u3002\u8fd9\u518d\u6b21\u8868\u660e\u8010\u7acb\u514b\u00ae\u8fd9\u4e00\u4e2d\u56fd\u539f\u521b\u7684\u5168\u7403best-in-class\u65b0\u836f\u6709\u671b\u89e3\u51b3\u5168\u7403CML\u548cPh+ ALL\u60a3\u8005\u7684\u4e34\u5e8a\u6025\u9700\u3002”\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a”\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42’\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002”<\/p>\n

\u6b64\u9879\u7814\u7a76\u57282023 ASH\u5e74\u4f1a\u4e0a\u5c55\u793a\u7684\u6838\u5fc3\u8981\u70b9\u5982\u4e0b\uff1a<\/p>\n

\u7814\u7a76\u8fdb\u5c55\uff1a\u5965\u96f7\u5df4\u66ff\u5c3c\uff08HQP1351\uff09\u53ef\u514b\u670d\u65e2\u5f80\u63a5\u53d7\u8fc7\u6df1\u5ea6\u6cbb\u7597\/\u96be\u6cbb\u6027
\n\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff08CML\uff09\u548c\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08Ph+ ALL\uff09\u60a3\u8005\u5bf9Ponatinib\u548c\/\u6216Asciminib\u8010\u836f<\/p>\n

\u5c55\u793a\u5f62\u5f0f\uff1a\u58c1\u62a5\u5c55\u793a<\/p>\n

\u6458\u8981\u7f16\u53f7\uff1a1798<\/p>\n

\u5206\u4f1a\u573a\uff1a632.\u6162\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\u8fdb\u5c55\uff1a\u58c1\u62a5 I<\/p>\n

\u62a5\u544a\u65f6\u95f4\uff1a2023\u5e7412\u67089\u65e5\uff0c\u661f\u671f\u516d\uff0c\u4e0b\u53485:30 – 7:30\uff08\u7f8e\u56fd\u897f\u90e8\u65f6\u95f4\uff09\/ 2023\u5e7412\u670810\u65e5\uff0c\u661f\u671f\u65e5\uff0c\u4e0a\u53489:30 \u2013 11:30\uff08\u5317\u4eac\u65f6\u95f4\uff09<\/p>\n

\u6838\u5fc3\u8981\u70b9\uff1a<\/p>\n

\u7814\u7a76\u80cc\u666f\uff1a\u7ecf\u7b2c\u4e00\u4ee3\u548c\u7b2c\u4e8c\u4ee3\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKIs\uff09\u6cbb\u7597\u5931\u8d25\u7684 CML \u60a3\u8005\u9884\u540e\u8f83\u5dee\u3002\u5965\u96f7\u5df4\u66ff\u5c3c\u662f\u4e00\u79cd\u65b0\u578b\u7b2c\u4e09\u4ee3TKI\uff0c\u5728CML\u548cPh+ ALL\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u5f88\u5f3a\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u672c\u6458\u8981\u65e8\u5728\u62a5\u544a\u8be5\u836f\u7269\u5728\u4e2d\u56fd\u4ee5\u5916\u7684CML\u548cPh+ All\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u7279\u5f81\uff0c\u7279\u522b\u662f\u90a3\u4e9b\u66fe\u63a5\u53d7\u8fc7\u7b2c\u4e09\u4ee3TKI ponatinib\u548c\/\u6216\u53d8\u6784\u6291\u5236\u5242asciminib\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n

\u7814\u7a76\u65b9\u6cd5\uff1a\u5965\u96f7\u5df4\u66ff\u5c3c\u91c7\u7528\u9694\u65e5\u7ed9\u836f\uff08QOD\uff09\u7684\u65b9\u5f0f\u3002\u5355\u836f\u6cbb\u7597\u961f\u5217\u4e2d\u7eb3\u5165\u7684\u60a3\u8005\u81f3\u5c11\u5bf92\u79cdTKI\u8010\u836f\u6216\u4e0d\u8010\u53d7\uff08\u5bf9\u4e8e\u643aT315I\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u65e2\u5f80\u4f7f\u7528TKI\u6570\u91cf\u4e0d\u505a\u9650\u5236\uff09\uff0c\u4ed6\u4eec\u88ab\u968f\u673a\u5206\u914d\u81f3\u5965\u96f7\u5df4\u66ff\u5c3c 30\u300140\u621650 mg\u5242\u91cf\u7ec4\u4e2d\uff0c28\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u8054\u5408\u6cbb\u7597\u961f\u5217\u7eb3\u5165\u7684\u60a3\u8005\u4e3a\u81f3\u5c11\u5bf91\u4e2a\u4e8c\u4ee3TKI\u8010\u836f\u7684Ph+\u524d\u4f53B\u7ec6\u80de ALL\uff08BCP ALL\uff09\u60a3\u8005\u6216CML\u6025\u6dcb\u53d8\uff08CML-LBP\uff09\u60a3\u8005\uff0c\u4ed6\u4eec\u63a5\u53d7\u4e86\u5965\u96f7\u5df4\u66ff\u5c3c\uff0830\u621640 mg\uff09\u4e0eCD19\/CD3\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u8854\u63a5\u5668\uff09blinatumomab\u7684\u8054\u5408\u6cbb\u7597\u3002<\/p>\n

\u5165\u7ec4\u60a3\u8005\uff1a\u622a\u81f32023\u5e746\u670830\u65e5\uff0c\u5171\u670976\u4f8b\u60a3\u8005\u5165\u7ec4\uff0c\u5305\u62ec57\u4f8bCML-\u6162\u6027\u671f\uff08CML-CP\uff09\u60a3\u8005\u548c19\u4f8b\u8fdb\u5c55\u671fPh+ \u767d\u8840\u75c5\uff08CML-AP, CML-LBP, Ph+ ALL\uff09\u60a3\u8005\u3002\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u5e74\u9f84\u4e3a54.5\u5c81\uff0821-80\u5c81\uff09\uff0c56.6%\u7684\u60a3\u8005\u4e3a\u7537\u6027\u3002<\/p>\n

\u5206\u522b\u670911\u4f8b\uff0814.5%\uff09\u300123\u4f8b\uff0830.3%\uff09\u548c39\u4f8b\uff0851.3%\uff09\u60a3\u8005\u63a5\u53d7\u8fc72\u30013\u548c \u22654\u79cdTKI\u6cbb\u7597\u3002
\n\u5171\u670940\u4f8b\uff0852.6%\uff09\u60a3\u8005\u66fe\u63a5\u53d7\u8fc7ponatinib\u6cbb\u7597\uff0c\u5176\u4e2d67.5%\u7684\u60a3\u8005\u5bf9ponatinib\u8010\u836f\uff1b25.0%\u7684\u60a3\u8005\u4e0d\u8010\u53d7\uff1b7.5%\u7684\u60a3\u8005\u56e0\u5176\u4ed6\u539f\u56e0\u6cbb\u7597\u5931\u8d25\u3002
\n\u5171\u670921\u4f8b\uff0827.6%\uff09\u60a3\u8005\u66fe\u63a5\u53d7\u8fc7asciminib\u6cbb\u7597\uff0c\u5176\u4e2d71.4%\u7684\u60a3\u8005\u5bf9asciminib\u8010\u836f\uff1b19.1%\u7684\u60a3\u8005\u4e0d\u8010\u53d7\uff1b9.5%\u7684\u60a3\u8005\u56e0\u5176\u4ed6\u539f\u56e0\u6cbb\u7597\u5931\u8d25\u3002
\n31.6%\u7684\u60a3\u8005\u57fa\u7ebf\u5408\u5e76T315I\u7a81\u53d8\uff1b38.2%\u7684\u60a3\u8005\u60a3\u6709\u9ad8\u8840\u538b\u3002
\n\u60a3\u8005\u7684\u4e2d\u4f4d\uff08\u8303\u56f4\uff09\u6cbb\u7597\u6301\u7eed\u65f6\u95f4\u4e3a24.1\u5468\uff080-134\u5468\uff09\u3002PK\u5206\u6790\u663e\u793a\u5168\u7403\u60a3\u8005\u7684PK\u7ed3\u679c\u4e0e\u4e2d\u56fd\u60a3\u8005\u7684\u5386\u53f2PK\u6570\u636e\u6ca1\u6709\u663e\u8457\u5dee\u5f02\u3002
\n\u7597\u6548\uff1a<\/p>\n

\u572850\u4f8b\u7597\u6548\u53ef\u8bc4\u4f30\u7684CML-CP\u60a3\u8005\u4e2d\uff0c56.8%\uff0825\/44\u4f8b\uff09\u7684\u60a3\u8005\u83b7\u5b8c\u5168\u7ec6\u80de\u5b66\u53cd\u5e94\uff08CCyR\uff09\uff1b42.9%\uff0821\/49\u4f8b\uff09\u7684\u60a3\u8005\u83b7\u4e3b\u8981\u5206\u5b50\u5b66\u53cd\u5e94\uff08MMR\uff09\u3002\u5176\u4e2d\uff0c\u5728\u643a\u5e26T315I\u7a81\u53d8\u7684CML-CP\u60a3\u8005\u4e2d\uff0cCCyR\u7387\u548cMMR\u7387\u5206\u522b\u4e3a60.0%\uff089\/15\uff09\u548c43.8%\uff087\/16\uff09\uff1b\u800c\u5728\u672a\u643a\u5e26T315I\u7a81\u53d8\u7684\u60a3\u8005\u4e2d\uff0cCCyR\u7387\u548cMMR\u7387\u5206\u522b\u4e3a55.2%\uff0816\/29\uff09\u548c42.4%\uff0814\/33\uff09\uff1b\u5728ponatinib\u8010\u836f\u7684\u60a3\u8005\u4e2d\uff0cCCyR\u7387\u548cMMR\u7387\u5206\u522b\u4e3a53.3%\uff088\/15\uff09\u548c37.5%\uff086\/16\uff09\uff1b\u5728asciminib\u6cbb\u7597\u8010\u836f\u7684\u60a3\u8005\u4e2d\uff0cCCyR\u7387\u548cMMR\u7387\u5206\u522b\u4e3a42.9%\uff083\/7\uff09\u548c37.5%\uff083\/8\uff09\u3002
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