{"id":2592,"date":"2022-12-14T11:47:57","date_gmt":"2022-12-14T03:47:57","guid":{"rendered":"http:\/\/zhantu.gshlw.com\/?p=2592"},"modified":"2022-12-14T11:47:57","modified_gmt":"2022-12-14T03:47:57","slug":"%e4%ba%9a%e7%9b%9b%e5%8c%bb%e8%8d%af%e5%8f%a3%e5%a4%b4%e6%8a%a5%e5%91%8aapg-2575%e8%81%94%e5%90%88btk%e6%8a%91%e5%88%b6%e5%89%82%e6%b2%bb%e7%96%97r-r-cll-sll%e6%82%a3%e8%80%85%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"http:\/\/zhantu.gshlw.com\/2592.html","title":{"rendered":"\u4e9a\u76db\u533b\u836f\u53e3\u5934\u62a5\u544aAPG-2575\u8054\u5408BTK\u6291\u5236\u5242\u6cbb\u7597R\/R CLL\/SLL\u60a3\u8005\u6570\u636e\u4eae\u773c"},"content":{"rendered":"

\u3010\u76f4\u51fb2022 ASH\u3011ORR\u8fbe98%\uff01\u4e9a\u76db\u533b\u836f\u53e3\u5934\u62a5\u544aAPG-2575\u8054\u5408BTK\u6291\u5236\u5242\u6cbb\u7597R\/R CLL\/SLL\u60a3\u8005\u6570\u636e\u4eae\u773c<\/strong><\/p>\n

\u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022022\u5e7412\u670813\u65e5 \/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49\u6cbb\u7597\u9886\u57df\u5f00\u53d1\u521b\u65b0\u836f\u7269\u7684\u9886\u5148\u7684\u751f\u7269\u533b\u836f\u4f01\u4e1a — \u4e9a\u76db\u533b\u836f\uff086855.HK\uff09\u4eca\u65e5\u5ba3\u5e03\uff0c\u516c\u53f8\u5df2\u5728\u7f8e\u56fd\u8def\u6613\u65af\u5b89\u90a3\u5dde\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7b2c64\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08American Society of Hematology\uff0cASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u4ee5\u53e3\u5934\u62a5\u544a\u5f62\u5f0f\u516c\u5e03\u4e86\u7ec6\u80de\u51cb\u4ea1\u7ba1\u7ebf\u91cd\u8981\u54c1\u79cdAPG-2575\u5355\u836f\u6216\u4e0eCALQUENCE\u00ae\uff08acalabrutinib\uff09\u53ca\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u521d\u6cbb\u3001\u590d\u53d1\u6216\u96be\u6cbb\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08R\/R CLL\/SLL\uff09\u60a3\u8005\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u7814\u7a76\u521d\u6b65\u6570\u636e\u3002<\/p>\n

ASH\u5e74\u4f1a\u662f\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u89c4\u6a21\u6700\u5927\u7684\u56fd\u9645\u5b66\u672f\u76db\u4f1a\u4e4b\u4e00\uff0c\u6c47\u96c6\u4e86\u6700\u524d\u6cbf\u7684\u7814\u7a76\u8fdb\u5c55\u53ca\u6700\u65b0\u7684\u836f\u7269\u7814\u53d1\u6570\u636e\uff0c\u5c55\u793a\u5168\u7403\u8840\u6db2\u5b66\u9886\u57df\u7684\u6700\u9ad8\u5b66\u672f\u6c34\u5e73\u3002\u4f5c\u4e3a\u65e5\u76ca\u6d3b\u8dc3\u5728\u56fd\u9645\u5b66\u672f\u821e\u53f0\u4e0a\u7684\u201c\u4e2d\u56fd\u58f0\u97f3\u201d\uff0c\u4e9a\u76db\u533b\u836f\u5728\u4eca\u5e74\u7684ASH\u5e74\u4f1a\u4e0a\uff0c\u901a\u8fc74\u9879\u53e3\u5934\u62a5\u544a\u53d1\u5e03\u4e865\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6570\u636e\uff0c\u6b64\u5916\uff0c\u516c\u53f8\u6838\u5fc3\u54c1\u79cd\u76f8\u5173\u8fdb\u5c55\u8fd8\u83b7\u90094\u9879\u58c1\u62a5\u5c55\u793a\uff0c\u5176\u4e2d3\u9879\u4e3a\u72ec\u7acb\u7814\u7a76\u8005\u57fa\u4e8e\u771f\u5b9e\u4e16\u754c\u7684\u7814\u7a76\u3002<\/p>\n

\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u7814\u7a76\u6570\u636e\u663e\u793a\u4e86\u4e9a\u76db\u533b\u836f\u7684\u81ea\u7814Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u5728R\/R CLL\/SLL\u60a3\u8005\u4e2d\u5f3a\u52b2\u7684\u5355\u836f\u548c\u8054\u5408\u6cbb\u7597\u6f5c\u529b\uff1aAPG-2575\u5355\u836f\u6cbb\u7597\u7684\u7814\u7a76\u7ed3\u679c\u548c\u524d\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u76f8\u4f3c\uff1bAPG-2575\u8054\u5408\u7597\u6cd5\u663e\u793a\u4e86\u8d85\u9ad8\u7684\u5ba2\u89c2\u53cd\u5e94\u7387\uff08ORR\uff09\uff0c\u5176\u4e2d\u8054\u5408acalabrutinib\u5728\u590d\u53d1\u96be\u6cbb\u60a3\u8005\u4e2d\u7684ORR\u8fbe\u523098%\u3002\u800c\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0c\u8054\u5408\u6cbb\u7597\u4fdd\u6301\u4e86\u4e0eAPG-2575\u5355\u836f\u6cbb\u7597\u76f8\u5f53\u7684\u4f4e\u80bf\u7624\u6eb6\u89e3\u7efc\u5408\u5f81\uff08TLS\uff09\u7684\u53d1\u751f\u7387\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e0e\u540c\u7c7b\u4ea7\u54c1\u7684\u4e94\u5468\u68af\u5ea6\u9012\u589e\u65b9\u6848\u4e0d\u540c\uff0cAPG-2575\u91c7\u7528\u6bcf\u65e5\u68af\u5ea6\u5242\u91cf\u9012\u589e\u7ed9\u836f\u7684\u65b9\u5f0f\uff0c\u57284-6\u5929\u5185\u5b8c\u6210\u5242\u91cf\u9012\u589e\uff0c\u7ed9\u836f\u65b9\u6848\u7b80\u6d01\u4fbf\u5229\uff0c\u4e14\u53ef\u4ee5\u8ba9\u53d7\u8bd5\u8005\u5f97\u4ee5\u66f4\u65e9\u5730\u63a5\u53d7\u6cbb\u7597\u5242\u91cf\u3002<\/p>\n

Acalabrutinib\u662f\u65b0\u4e00\u4ee3\u9009\u62e9\u6027\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08BTKi\uff09\uff0c\u4e9a\u76db\u533b\u836f\u4e8e2020\u5e746\u6708\u4e0e\u963f\u65af\u5229\u5eb7\u8840\u6db2\u7814\u53d1\u5353\u8d8a\u4e2d\u5fc3\uff08Acerta Pharma B.V.\uff09\u8fbe\u6210\u4e34\u5e8a\u7814\u7a76\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u5c31\u4e9a\u76db\u533b\u836f\u5728\u7814Bcl-2\u9009\u62e9\u6027\u6291\u5236\u5242APG-2575\u4e0eAcerta \u7684\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u6291\u5236\u5242acalabrutinib\u7684\u8054\u5408\u6cbb\u7597\u5c55\u5f00\u4e34\u5e8a\u7814\u7a76\uff0c\u6b64\u6b21\u53e3\u5934\u62a5\u544a\u7684\u6570\u636e\u4e3a\u8be5\u8054\u5408\u7814\u7a76\u7684\u6570\u636e\u9996\u6b21\u516c\u5e03\u3002<\/p>\n

\u8be5\u9879\u4e34\u5e8a\u7814\u7a76\u7684\u5168\u7403\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u7f8e\u56fd\u9a6c\u8d5b\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662\uff08Dana-Farber Cancer Institute\uff09\u7684Matthew S. Davids\u535a\u58eb\u8868\u793a\uff1a\u201c\u6b64\u6b21\u516c\u5e03\u7684\u7ed3\u679c\u663e\u793a\uff0cAPG-2575\u8054\u5408BTK\u6291\u5236\u5242acalabrutinib\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe\u5230\u7ea698%\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u89c2\u5bdf\u5230\u826f\u597d\u7684\u5b89\u5168\u6027\u4ee5\u53ca\u6bcf\u65e5\u5242\u91cf\u9012\u589e\u4e0b\u4ecd\u7136\u6781\u4f4e\u7684TLS\u53d1\u751f\u7387\u3002\u8fd9\u4e9b\u7ed3\u679c\u518d\u6b21\u5370\u8bc1\u4e86\u8fd9\u6b3eBcl-2\u6291\u5236\u5242\u6cbb\u7597CLL\/SLL\u7684\u4e34\u5e8a\u6f5c\u529b\u3002\u201d<\/p>\n

\u4e9a\u76db\u533b\u836f\u9996\u5e2d\u533b\u5b66\u5b98\u7fdf\u4e00\u5e06\u535a\u58eb\u8868\u793a\uff1a\u201c\u6b64\u6b21\u516c\u5e03\u7684\u6570\u636e\u518d\u4e00\u6b21\u5c55\u73b0\u4e86APG-2575\u5728R\/R CLL\/SLL\u6cbb\u7597\u9886\u57df\u7684\u65e0\u9650\u6f5c\u529b\uff0cBcl-2\u6291\u5236\u5242\u4e0eBTK\u6291\u5236\u5242\u7684\u8054\u5408\u6cbb\u7597\u524d\u666f\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\u4e0e\u671f\u5f85\u3002\u6b64\u6b21\u6211\u4eec\u9996\u6b21\u516c\u5e03\u4e86APG-2575\u4e0eBTK\u6291\u5236\u5242acalabrutinib\u8054\u5408\u6cbb\u7597\u6570\u636e\uff0c\u8d85\u9ad8\u7684ORR\u4ee4\u4eba\u65e0\u6bd4\u632f\u594b\u3002<\/p>\n

\u4eca\u5e74\uff0c\u7814\u7a76\u4eba\u5458\u5728ASH\u5e74\u4f1a\u4e0a\u901a\u8fc74\u9879\u53e3\u5934\u62a5\u544a\u516c\u5e03\u4e86\u516c\u53f8\u6838\u5fc3\u54c1\u79cdAPG-2575\u548c\u8010\u7acb\u514b\u00ae\uff08\u5965\u96f7\u5df4\u66ff\u5c3c\uff09\u7684\u6700\u65b0\u6570\u636e\u3002\u5bf9\u6b64\u6211\u611f\u5230\u975e\u5e38\u81ea\u8c6a\uff0c\u56e0\u4e3a\u8fd9\u662f\u4e9a\u76db\u533b\u836f\u5168\u7403\u521b\u65b0\u80fd\u529b\u7684\u4f53\u73b0\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u79c9\u6301\u521d\u5fc3\uff0c\u575a\u5b88\u2018\u89e3\u51b3\u4e2d\u56fd\u4e43\u81f3\u5168\u7403\u60a3\u8005\u5c1a\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u2019\u8fd9\u4e00\u4f7f\u547d\uff0c\u52a0\u5feb\u4e34\u5e8a\u5f00\u53d1\uff0c\u8ba9\u5b89\u5168\u6709\u6548\u7684\u836f\u7269\u5c3d\u5feb\u4e0a\u5e02\uff0c\u65e9\u65e5\u60e0\u53ca\u60a3\u8005\u3002\u201d<\/p>\n

APG-2575\u57282022 ASH\u5e74\u4f1a\u4e0a\u53e3\u5934\u62a5\u544a\u7684\u7814\u7a76\u6458\u8981\u5982\u4e0b\uff1a\uff08\u8010\u7acb\u514b\u00ae\u76f8\u5173\u53e3\u5934\u62a5\u544a\u7814\u7a76\u6458\u8981\u7684\u8be6\u7ec6\u4fe1\u606f\u53c2\u89c1\u4e9a\u76db\u533b\u836f\u5728\u4eca\u5e74ASH\u5e74\u4f1a\u95f4\u53d1\u5e03\u7684\u53e6\u5916\u4e24\u7bc7\u65b0\u95fb\u7a3f\uff09<\/p>\n

Lisaftoclax (APG-2575) Safety and Activity as Monotherapy or Combined with Acalabrutinib or Rituximab in Patients (pts) with Treatment-Na\u00efve, Relapsed or Refractory Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (R\/R CLL\/SLL): Initial Data from a Phase 2 Global Study<\/p>\n

Lisaftoclax\uff08APG-2575\uff09\u5355\u836f\u6216\u4e0eAcalabrutinib\/\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u5728\u521d\u6cbb\u3001\u590d\u53d1\u6216\u96be\u6cbb\u7684\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\/\u5c0f\u6dcb\u5df4\u7ec6\u80de\u6dcb\u5df4\u7624\uff08R\/R CLL\/SLL\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6297\u80bf\u7624\u6d3b\u6027\uff1a\u6765\u81ea\u4e00\u9879II\u671f\u5168\u7403\u6027\u4e34\u5e8a\u7814\u7a76\u7684\u521d\u6b65\u6570\u636e<\/p>\n

\u5c55\u793a\u5f62\u5f0f\uff1a\u53e3\u5934\u62a5\u544a
\n\u6458\u8981\u7f16\u53f7\uff1a#160386
\n\u5206\u4f1a\u573a\uff1a642.\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff1a\u4e34\u5e8a\u53ca\u6d41\u884c\u75c5\u5b66\uff1a\u5728\u7814\u836f\u7269\u548c\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3
\n\u62a5\u544a\u65f6\u95f4\uff1a\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f42022\u5e7412\u670812\u65e5\uff0c\u661f\u671f\u4e00\uff0c\u4e0b\u53485:15\/\u5317\u4eac\u65f6\u95f42022\u5e7412\u670813\u65e5\uff0c\u661f\u671f\u4e8c\uff0c\u65e9\u4e0a6:15
\n\u6838\u5fc3\u8981\u70b9\uff1a
\n-APG-2575\u662f\u4e00\u79cd\u7279\u5f02\u6027Bcl-2\u6291\u5236\u5242\uff0c\u5728R\/R CLL\/SLL\u60a3\u8005\u4e2d\u5177\u6709\u6d3b\u6027\uff0c\u5305\u62ec\u7ecfBTKi\u6cbb\u7597\u540e\u75be\u75c5\u8fdb\u5c55\uff08PD\uff09\u4e14\u4f34\u6709del\uff0817p\uff09\u7684\u60a3\u8005\u3002\u8fd9\u662fAPG-2575\u8054\u5408acalabrutinib\u6216\u5229\u59a5\u6614\u5355\u6297\u7528\u4e8eR\/R CLL\/SLL\u60a3\u8005\u7684\u6570\u636e\u9996\u6b21\u62a5\u544a\u3002<\/p>\n

-\u60a3\u8005\u6bcf\u5929\u5355\u72ec\u53e3\u670dAPG-2575\uff08400mg\uff0c600mg\u548c800mg\uff09\u6216\u4e0eacalabrutinib\u6301\u7eed\u8054\u7528\/\u5229\u59a5\u6614\u5355\u6297\u8054\u75286\u4e2a\u5468\u671f\uff0c\u6bcf28\u5929\u4e3a\u4e00\u5468\u671f\u3002\u4e3b\u8981\u76ee\u7684\u4e3a\u786e\u5b9aII\u671f\u7814\u7a76\u63a8\u8350\u5242\u91cf\uff08RP2D\uff09\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5305\u62ecAPG-2575\u5355\u836f\u53ca\u8054\u5408acalabrutinib\u6216\u5229\u59a5\u6614\u5355\u6297\u7684ORR\u3002\u5728\u76d1\u6d4bTLS\u524d\u63d0\u4e0b\uff0c\u60a3\u8005\u91c7\u7528\u6bcf\u5929\u68af\u5ea6\u9012\u589e\u7ed9\u836f\u7684\u65b9\u5f0f\uff0c4-6\u5929\u540e\u53ef\u8fbe\u5230\u6700\u7ec8\u76ee\u6807\u5242\u91cf\uff0c\u968f\u540e\u7b2c1\u5468\u671f\u7b2c1\u5929\uff08C1D1\uff09APG-2575 \u7684\u76ee\u6807\u5242\u91cf\u4e3a400\u3001600\u6216800mg\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\u7684\u60a3\u8005\u5728\u5b8c\u6210\u68af\u5ea6\u9012\u589e\u7ed9\u836f\u8fbe\u5230\u76ee\u6807\u5242\u91cf\u540e\uff0c\u7ee7\u7eed\u63a5\u53d7\u989d\u59167\u5929\u7684APG-2575\u5148\u5bfc\u6cbb\u7597\uff0c\u7136\u540e\u5728C1D8\u65f6\u52a0\u5165acalabrutinib\/\u5229\u59a5\u6614\u5355\u6297\uff0c\u76f4\u81f3PD\u6216\u8005\u89c2\u5bdf\u5230\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n

-\u622a\u6b622022\u5e7412\u67085\u65e5\uff0c\u5171\u5165\u7ec4164\u4f8b\u60a3\u8005\u3002APG-2575\u5355\u836f\u7ec4\u5171\u5165\u7ec446\u4f8b\u60a3\u8005\uff0c\u4e2d\u4f4d\u5e74\u9f8460.5\u5c81\uff0841-80\uff09\u3002\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u7ec4\u5171\u5165\u7ec4\u4e8639\u4f8b\u60a3\u8005\uff0c\u4e2d\u4f4d\u5e74\u9f8464\u5c81\uff0834-75\uff09\u3002acalabrutinib\u8054\u5408\u7ec4\u5171\u5165\u7ec4\u4e8679\u4f8b\u60a3\u8005\uff0c\u4e2d\u4f4d\u5e74\u9f8464\u5c81\uff0818-80\uff09\u3002\u603b\u4eba\u7fa4\u4e2d16\u4f8b\uff089.8%\uff09\u4e3a\u521d\u6cbb\u60a3\u8005\uff0c\u517119\u4f8b\uff0811.6%\uff09\u60a3\u8005\u65e2\u5f80\u4f7f\u7528\u8fc7BTKi\u6cbb\u7597\u3002\u8054\u5408\u7ec4\u4e2d\uff08n=118\uff09\uff0cTP53\u7a81\u53d8\u548c\/\u6216\u4f34del\uff0817p\uff09\u670925\u4f8b\uff0c IGHV\u672a\u7a81\u53d8\u670934\u4f8b\u3002\u4e2d\u4f4d\u6cbb\u7597\u65f6\u95f4\uff1a\u5355\u836f\u7ec4APG-2575\u4e3a16.5\uff081-36\uff09\u4e2a\u5468\u671f\uff0c\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u7ec411\uff080-21\uff09\u4e2a\u5468\u671f\uff0cacalabrutinib\u8054\u5408\u7ec411\uff081-24\uff09\u4e2a\u5468\u671f\u3002<\/p>\n

-\u5b89\u5168\u6027\uff1a\u5e38\u89c1\u7684\u4efb\u4f55\u7ea7\u522b\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5305\u62ec\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8179\u6cfb\u548c\u611f\u67d3\u3002APG-2575\u5355\u836f\u7ec4\u4e2d3\u7ea7\u53ca\u4ee5\u4e0aAE\u4e3b\u8981\u5305\u62ec\uff1a\u7c92\u7ec6\u80de\u51cf\u5c11\uff0830.3%\uff09\u3001\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\uff0828%\uff09\u3001\u8d2b\u8840\uff0815%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff086.5%\uff09\u3001\u80ba\u708e\uff086.5%\uff09\uff1b\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u7ec43\u7ea7\u53ca\u4ee5\u4e0aAE\u4e3b\u8981\u5305\u62ec\u7c92\u7ec6\u80de\u51cf\u5c11\uff0821%\uff09\u3001\u8d2b\u8840\uff088%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff085%\uff09\uff1bacalabrutinib\u8054\u5408\u7ec4\u4e2d3\u7ea7\u53ca\u4ee5\u4e0aAE\u4e3b\u8981\u5305\u62ec\u7c92\u7ec6\u80de\u51cf\u5c11\uff0823%\uff09\u3001\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\uff0811.5%\uff09\u3001\u8d2b\u8840\uff0810%\uff09\u3001\u8840\u5c0f\u677f\u51cf\u5c11\uff086.4%\uff09\u3002\u9996\u6b213\u7ea7\u53ca\u4ee5\u4e0a\u7684\u8840\u7ec6\u80de\u51cf\u5c11\u4e3b\u8981\u53d1\u751f\u5728\u68af\u5ea6\u9012\u589e\u6216C1\u671f\u95f4\uff0c\u7f55\u89c1\u4e8eC2\u4e4b\u540e\u3002\u60a3\u8005\u5728\u751f\u957f\u56e0\u5b50\u652f\u6301\u4e0b\u22653\u7ea7\u7684\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u7684\u4e0d\u826f\u4e8b\u4ef6\u53ef\u63a7\u3002\u5171\u67094\u4f8b\u60a3\u8005\u53d1\u751fTLS\uff082\u4f8b\u4e34\u5e8aTLS\uff0c2\u4f8b\u5b9e\u9a8c\u5ba4TLS\uff09\u3002\u53d1\u751f\u4e34\u5e8aTLS\u76842\u4f8b\u60a3\u8005\u6700\u7ec8\u5747\u5b8c\u5168\u6062\u590d\uff0c\u4e14\u5728600mg\u5242\u91cf\u7ec4\u83b7\u5f97\u7597\u6548\u3002\u672a\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6bd2\u6027\uff08DLT\uff09\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u4e2d\u672a\u53d1\u73b0\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

-\u521d\u6b65\u7597\u6548\uff1a\u5355\u836f\u7ec4\u4e2d\uff0c\u60a3\u8005\u7684ORR\u8fbe67%\uff0829\/43\uff09\u5176\u4e2d\u65e2\u5f80\u63a5\u53d7BTKi\u96be\u6cbb\u6216\u8005\u4e0d\u8010\u53d7\u60a3\u8005\u7684ORR\u8fbe67% (4\/6)\uff1b\u5728acalabrutinib\u8054\u5408\u7ec4\u4e2d\uff0c\u60a3\u8005\u7684ORR\u8fbe98.6%\uff0872\/73\uff09\uff0c\u5176\u4e2d\u5728\u590d\u53d1\/\u96be\u6cbb\u4eba\u7fa4\u4e2d\u7684ORR\u8fbe98%\uff0856\/57\uff09\uff0c\u521d\u6cbb\u4eba\u7fa4100%\uff0816\/16\uff09\uff0c\u65e2\u5f80BTKi\u96be\u6cbb\u6216\u8005\u4e0d\u8010\u53d7\u60a3\u8005\u7684ORR\u8fbe88% (7\/8)\uff1b\u5728\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u7ec4\u4e2d\uff0c\u60a3\u8005\u7684ORR\u8fbe79%\uff0827\/34\uff09\u3002<\/p>\n

-\u7ed3\u8bba\uff1a\u5728\u521d\u6cbb\u53caR\/R CLL\/SLL\u60a3\u8005\u4e2d\uff0c\u6bcf\u65e5\u68af\u5ea6\u5242\u91cf\u9012\u589e\u7ed9\u836f\u7684\u60c5\u51b5\u4e0b\uff0cAPG-2575\u5355\u836f\u6216\u4e0eacalabrutinib\/\u5229\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u53ef\u63a7\uff0c\u5e76\u5c55\u793a\u51fa\u4e86\u4f18\u5f02\u7684\u65e9\u671f\u7597\u6548\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u76f4\u51fb2022 ASH\u3011ORR\u8fbe98%\uff01\u4e9a\u76db\u533b\u836f\u53e3\u5934\u62a5\u544aAPG-2575\u8054\u5408BTK\u6291\u5236\u5242\u6cbb\u7597R\/R CLL\/SLL\u60a3\u8005\u6570\u636e\u4eae\u773c \u4e2d\u56fd\u82cf\u5dde\u548c\u7f8e\u56fd\u9a6c\u91cc\u5170\u5dde\u7f57\u514b\u7ef4\u5c14\u5e022022\u5e7412\u670813\u65e5 \/ — \u81f4\u529b\u4e8e\u5728\u80bf\u7624\u3001\u4e59\u809d\u53ca\u4e0e\u8870\u8001\u76f8\u5173\u75be\u75c5\u7b49 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"_links":{"self":[{"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/posts\/2592"}],"collection":[{"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/comments?post=2592"}],"version-history":[{"count":3,"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/posts\/2592\/revisions"}],"predecessor-version":[{"id":2596,"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/posts\/2592\/revisions\/2596"}],"wp:attachment":[{"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/media?parent=2592"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/categories?post=2592"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/zhantu.gshlw.com\/wp-json\/wp\/v2\/tags?post=2592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}