{"id":2250,"date":"2022-12-14T10:32:58","date_gmt":"2022-12-14T02:32:58","guid":{"rendered":"http:\/\/ww.gshlw.com\/?p=2250"},"modified":"2022-12-14T10:32:58","modified_gmt":"2022-12-14T02:32:58","slug":"%e5%92%8c%e5%89%82%e8%8d%af%e4%b8%9a%e5%b0%86%e5%9c%a8ash%e5%b9%b4%e4%bc%9a%e4%b8%8a%e5%b1%95%e7%a4%bacpi-818-i-ib-%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e6%9c%80%e6%96%b0%e6%95%b0%e6%8d%ae","status":"publish","type":"post","link":"http:\/\/ww.gshlw.com\/2250.html","title":{"rendered":"\u548c\u5242\u836f\u4e1a\u5c06\u5728ASH\u5e74\u4f1a\u4e0a\u5c55\u793aCPI-818 I\/Ib \u671f\u4e34\u5e8a\u8bd5\u9a8c\u6700\u65b0\u6570\u636e"},"content":{"rendered":"

\u590d\u53d1\/\u96be\u6cbb\u6027T \u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u7ed3\u679c\u8868\u660e CPI-818 \u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u540c\u65f6\u5b83\u5bf9 T \u7ec6\u80de\u5206\u5316\u7684\u5f71\u54cd\u8868\u660e\u5176\u5728 Th2 \u548cTh17\u4ecb\u5bfc\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u8fc7\u654f\u6027\u75be\u75c5\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b<\/p>\n

\u7535\u8bdd\u4f1a\u8bae\u548c\u7f51\u7edc\u76f4\u64ad\u5c06\u4e8e\u5317\u4eac\u65f6\u95f42022\u5e7412\u670813\u65e5 \u65e9\u66685\u70b930\u5206\u4e3e\u884c\uff08\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4 2022\u5e7412\u670812\u65e5 \u4e0b\u53484\u70b930\u5206\uff09<\/p>\n

\u4e2d\u56fd\u5609\u5174\u548c\u7f8e\u56fd\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u4f2f\u6797\u683c\u59c62022\u5e7412\u670812\u65e5 \/ — \u548c\u5242\u836f\u4e1a\uff0c\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u521b\u65b0\u836f\u516c\u53f8\uff0c\u4eca\u5929\u5ba3\u5e03\u8be5\u516c\u53f8\u4e0eCorvus Pharmaceuticals\u5171\u540c\u7814\u53d1\u7684\u5168\u7403first in class\u521b\u65b0\u836f ITK \u6291\u5236\u5242 CPI-818 \u7684 I\/Ib \u671f\u5168\u7403\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u7ed3\u679c\uff0c\u8bc1\u660e\u5b83\u5728 T \u7ec6\u80de\u6dcb\u5df4\u7624 (TCL) \u60a3\u8005\u4e2d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u53ca\u5176\u5728Th2\u548cTh17\u4ecb\u5bfc\u7684\u81ea\u8eab\u514d\u75ab\u6027\u548c\u8fc7\u654f\u6027\u75be\u75c5\u4e2d\u7684\u6cbb\u7597\u6f5c\u529b\u3002\u8fd9\u4e9b\u6570\u636e\u5c06\u4e8e\u4eca\u5929\u5728\u7b2c 64\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a (ASH) \u5e74\u4f1a\u4e0a\u4ee5\u58c1\u62a5\u5f62\u5f0f\u5c55\u793a\uff0c\u8be5\u5927\u4f1a\u4e8e 2022 \u5e74 12 \u6708 10 \u65e5\u81f3 13 \u65e5\u4ee5\u7ebf\u4e0a\u7ebf\u4e0b\u76f8\u7ed3\u5408\u7684\u65b9\u5f0f\u4e3e\u884c\u3002<\/p>\n

“CPI-818 ITK\u6291\u5236\u5242 \u5df2\u8bc1\u660e\u5728\u96be\u6cbb\u6027 T \u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\u5177\u6709\u5355\u836f\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8fd9\u4e9b\u60a3\u8005\u7684\u6cbb\u7597\u9009\u62e9\u6781\u5176\u6709\u9650\u4e14\u7f13\u89e3\u7387\u6781\u4f4e\u3002” \u548c\u5242\u836f\u4e1a\u8054\u5408\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957fRichard Miller\u535a\u58eb\u8bf4\uff0c”\u6211\u4eec\u5df2\u7ecf\u5728 200\u6beb\u514b\u5242\u91cf\u7ec411 \u540d\u53ef\u8bc4\u4f30\u60a3\u8005\u4e2d\u7684 4 \u540d\u4e2d\u770b\u5230\u4e86\u6301\u7eed\u7684\u5ba2\u89c2\u7f13\u89e3\u3002\u6839\u636e\u76ee\u524d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u548c\u5242\u836f\u4e1a\u4e0eCorvus Pharmaceuticals\u8ba1\u5212\u5728 2023 \u5e74\u4e2d\u5c06 CPI-818 \u63a8\u8fdb\u5230 T \u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u5168\u7403II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e2d\u56fd\u7684T\u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u53d1\u75c5\u7387\u548c\u60a3\u75c5\u7387\u76f8\u5bf9\u8f83\u9ad8\uff0c\u548c\u5242\u836f\u4e1a\u5c06\u5c55\u5f00\u4e2d\u56fd\u90e8\u5206\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7814\u7a76\u3002I \u671f\u6570\u636e\u8fd8\u63d0\u4f9b\u4e86\u4f53\u5185\u8bc1\u636e\uff0c\u8bc1\u660e CPI-818 \u80fd\u591f\u901a\u8fc7\u8bf1\u5bfcTh1\u7ec6\u80de\u504f\u659c\u548c\u963b\u65ad Th2\u4ee5\u53caTh17 \u7ec6\u80de\u6765\u8c03\u8282 T\u7ec6\u80de\u7684\u514d\u75ab\u529f\u80fd\u3002\u8fd9\u4e9b\u4f5c\u7528\u5bf9\u4e8e\u764c\u75c7\u6cbb\u7597\u5f88\u91cd\u8981 –Th1 \u7ec6\u80de\u5bf9\u4e8e\u6d88\u9664\u80bf\u7624\u7ec6\u80de\u81f3\u5173\u91cd\u8981–\u540c\u65f6\u4e5f\u5305\u62ecTh2\u548cTh17 \u7ec6\u80de\u53c2\u4e0e\u7684\u8bb8\u591a\u81ea\u8eab\u514d\u75ab\u6027\u548c\u8fc7\u654f\u6027\u75be\u75c5\u3002\u5728 ASH \u4e0a\u62a5\u544a\u7684\u4e34\u5e8a\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cCPI-818 \u53ef\u589e\u5f3a\u6297\u80bf\u7624\u514d\u75ab\uff0c\u4ee3\u8868\u4e86\u4e00\u79cd\u6f5c\u5728\u7684\u514d\u75ab\u6cbb\u7597\u65b0\u65b9\u6cd5\u3002”<\/p>\n

Miller \u535a\u58eb\u603b\u7ed3\u5230\uff0c”\u603b\u7684\u6765\u8bf4\uff0c\u6211\u4eec\u8ba4\u4e3a ASH\u4e0a\u5c55\u793a\u7684\u6570\u636e\u4e3a ITK \u6291\u5236\u5242\u6cbb\u7597\u6dcb\u5df4\u7624\u548c\u90e8\u5206\u514d\u75ab\u75be\u75c5\u63d0\u4f9b\u4e86\u575a\u5b9e\u7684\u7406\u8bba\u57fa\u7840\u3002CPI-818 \u662f\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684 ITK \u6291\u5236\u5242\uff0c\u5bf9 ITK \u5177\u6709\u9ad8\u9009\u62e9\u6027\uff0c\u6211\u4eec\u8ba4\u4e3a\u8fd9\u5bf9\u4e8e\u5b9e\u73b0\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u514d\u75ab\u8c03\u8282\u529f\u80fd\u81f3\u5173\u91cd\u8981\uff0c\u4ee3\u8868\u4e86\u6211\u4eec\u7814\u53d1\u56e2\u961f\u7684\u4e00\u9879\u91cd\u5927\u6210\u5c31\u3002” \u548c\u5242\u836f\u4e1a\u8054\u5408\u521b\u59cb\u4eba\u738b\u94c1\u98de\u535a\u58eb\u8bf4\uff1a “CPI-818 \u5168\u7403\u4e34\u5e8aI\/Ib\u671f\u7684\u6210\u529f\u5f00\u5c55\u5145\u5206\u663e\u793a\u4e86\u548c\u5242\u836f\u4e1a\u4e0eCorvus Pharmaceuticals\u5728\u5171\u540c\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u4f18\u52bf\u4e92\u8865\u3001\u8d44\u6e90\u5171\u4eab\u7684\u4f18\u52bf\uff0c\u671f\u5f85\u53cc\u65b9\u7ee7\u7eed\u5408\u4f5c\u9ad8\u6548\u63a8\u52a8CPI-818\u7684\u5168\u7403\u5f00\u53d1\u8fdb\u7a0b\u3002”<\/p>\n

CPI-818\u4e34\u5e8aI\/Ib\u671f\u4e2d\u56fd\u9886\u5bfc\u7814\u7a76\u8005\uff0c\u5317\u4eac\u5927\u5b66\u80bf\u7624\u533b\u9662\u6dcb\u5df4\u7624\u79d1\u5b8b\u7389\u7434\u6559\u6388\u8868\u793a”CPI-818\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\u7684ITK\u6291\u5236\u5242\uff0c\u5728I\/Ib\u671f\u5df2\u6709\u7684\u6570\u636e\u5df2\u7ecf\u8bc1\u660e\u4e86\u5176\u5b89\u5168\u6027\u4ee5\u53ca\u4e00\u5b9a\u7684\u5355\u836f\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u540c\u65f6\u83b7\u5f97\u4e86CPI-818\u80fd\u591f\u8c03\u8282T\u7ec6\u80de\u514d\u75ab\u529f\u80fd\u7684\u4f53\u5185\u8bc1\u636e\uff0c\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b9\u9762\u975e\u5e38\u6709\u6f5c\u529b\u3002\u5e0c\u671bCPI-818\u540e\u7eed\u5f00\u53d1\u987a\u5229\uff0c\u5c3d\u65e9\u4e3a\u4e2d\u56fd\u7684T\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u5e26\u6765\u798f\u97f3”\u3002<\/p>\n

CPI-818 I\/Ib \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u7ed3\u679c\u5728 ASH 2022 \u4e0a\u516c\u5e03<\/p>\n

CPI-818 \u6b63\u5728\u8fdb\u884c I\/Ib \u671f\u4e34\u5e8a\u8bd5\u9a8c\u5355\u836f\u6cbb\u7597\u590d\u53d1\u6027 TCL \u60a3\u8005\u7814\u7a76\u3002\u622a\u81f3 2022 \u5e74 9 \u67082\u65e5\uff0c\u5171\u6709 43 \u540d\u60a3\u8005\u53c2\u52a0\u4e86\u8be5\u8bd5\u9a8c\uff0c\u5206\u4e3a\u56db\u4e2a\u5242\u91cf\u9012\u589e\u961f\u5217\uff1a\u5242\u91cf\u5206\u522b\u4e3a 100\u3001200\u3001400 \u548c 600 \u6beb\u514b\u6bcf\u5929\u4e24\u6b21\u3002\u53d1\u73b0 200 \u6beb\u514b\u5242\u91cf\u63d0\u4f9b\u7684\u8840\u6d46\u836f\u7269\u6d53\u5ea6\u53ef\u8fbe\u5230\u5f71\u54cd\u4f53\u5916 T \u7ec6\u80de\u5206\u5316\u6700\u4f73\u6548\u679c\uff0c\u5e76\u76f8\u5e94\u5730\u5f15\u8d77\u4f53\u5185\u6700\u9891\u7e41\u548c\u6301\u4e45\u7684\u80bf\u7624\u54cd\u5e94\u3002\u56e0\u6b64\u8fd9\u88ab\u9009\u4e3a\u6700\u4f73\u5242\u91cf\uff0c\u5e76\u4e14\u6b63\u5728\u62db\u52df\u66f4\u591a\u60a3\u8005\u53c2\u52a0200 mg \u5242\u91cf\u961f\u5217\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002I\/Ib\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7814\u7a76\u7ec8\u70b9\u662f\u5b89\u5168\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u3001\u514d\u75ab\u6548\u5e94\u548c\u80bf\u7624\u54cd\u5e94\u3002<\/p>\n

T \u7ec6\u80de\u6dcb\u5df4\u7624\u7684\u4e2d\u671f\u6570\u636e\u4eae\u70b9<\/p>\n

13 \u540d\u60a3\u8005\u88ab\u7eb3\u5165 200 mg \u961f\u5217\uff0c\u5176\u4e2d 11 \u540d\u53ef\u8bc4\u4f30\u53cd\u5e94\uff0c\u7686\u4e3a\u91cd\u5ea6\u6cbb\u7597\u60a3\u8005\uff0c\u5e73\u5747\u63a5\u53d7\u8fc7 3 \u7ebf\u65e2\u5f80\u6cbb\u7597\uff0c11\u4f8b\u60a3\u8005\u4e2d\u67094\u4f8b\u51fa\u73b0\u603b\u4f53\u5ba2\u89c2\u7f13\u89e3\u3002\u5728\u8be5\u7ec4\u4e2d\uff0c\u4e00\u540d\u5916\u5468 T \u7ec6\u80de\u6dcb\u5df4\u7624 (PTCL) \u60a3\u8005\u83b7\u5f97\u4e86\u6301\u7eed 25 \u4e2a\u6708\u7684\u5b8c\u5168\u7f13\u89e3 (CR)\uff1b\u4e00\u540d\u76ae\u80a4 T \u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u6dcb\u5df4\u7ed3 CR \u6301\u7eed 19 \u4e2a\u6708\uff1b\u5728 PTCL \u548c\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u4e2d\uff0c\u5206\u522b\u5728 6 \u4e2a\u6708\u548c 8 \u4e2a\u6708\u7684\u968f\u8bbf\u4e2d\u51fa\u73b0\u4e86\u4e24\u4e2a\u6301\u7eed\u90e8\u5206\u7f13\u89e3 (PR)\u3002
\n\u6ca1\u6709\u89c2\u5bdf\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u5e76\u4e14\u5728\u9ad8\u8fbe 600 mg \u6bcf\u5929\u4e24\u6b21\u7684\u5242\u91cf\u4e0b\u672a\u8fbe\u5230\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002
\n\u6240\u6709\u4e0a\u8ff0\u6570\u636e\u5747\u622a\u81f32022\u5e749\u67082\u65e5\u3002
\n\u514d\u75ab\u6548\u679c\u7684\u4e2d\u671f\u6570\u636e\u4eae\u70b9<\/p>\n

\u622a\u81f32022\u5e749\u67082\u65e5\uff0c\u6839\u636e\u51e0\u540d\u60a3\u8005\u7684\u5916\u5468\u8840\u6837\u672c\uff0c\u663e\u793a 200 mg \u6700\u4f73\u5242\u91cf\u53ef\u8bf1\u5bfc Th1 \u504f\u659c\uff0cTh2\u53caTh17 \u963b\u65ad\uff1a
\n– \u5728\u4e00\u540d\u8179\u58c1\u5927\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u7684\u60a3\u8005\u4e2d\uff0c\u8840\u6837\u5206\u6790\u663e\u793a\u8840\u6db2 Th1 \u589e\u52a0\uff0c\u8840\u6db2 Th17 \u51cf\u5c11\uff0c\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u548c IL-5 \u5206\u6ccc\u51cf\u5c11\u4e0e Th1 \u504f\u659c\u548c Th2 \u963b\u65ad\u7684\u5224\u65ad\u4e00\u81f4\u3002\u5bf9\u8be5\u60a3\u8005\u7684\u80bf\u7624\u6837\u672c\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u7ed3\u679c\u663e\u793a\u7ec8\u672b\u5206\u5316\u7684 T \u6548\u5e94\u8bb0\u5fc6\u7ec6\u80de\uff08TEMRA \u7ec6\u80de\uff09\u6709\u6240\u589e\u52a0\uff0c\u8fd9\u4e9b T \u7ec6\u80de\u5177\u6709\u5448\u9012\u6297\u539f\u529f\u80fd\u548c\u4ecb\u5bfc\u6548\u5e94\u7684\u529f\u80fd\uff0c\u4f8b\u5982\u7834\u574f\u80bf\u7624\u7ec6\u80de\u3002<\/p>\n

– \u5728\u53e6\u5916\u56db\u540d\u60a3\u8005\uff08\u4e24\u540d\u60a3\u8005 PR\uff0c\u4e00\u540d\u60a3\u8005\u75be\u75c5\u7a33\u5b9a (SD) \u548c\u4e00\u540d\u60a3\u8005\u75be\u75c5\u8fdb\u5c55 (PD)\uff09\uff0c\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u6d4b\u91cf\u4e86 Th1 \u548c CD8+ TEMRA \u7ec6\u80de\u7684\u53d8\u5316\u3002PR \u548c SD \u60a3\u8005\u663e\u793a Th1 \u548c CD8+ TEMRA \u7ec6\u80de\u589e\u52a0 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cSD \u548c PD \u60a3\u8005\u5728\u57fa\u7ebf\u65f6\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff1a\u7edd\u5bf9\u8ba1\u6570 <1,000\uff0c\u8fd9\u8868\u660e\u60a3\u8005\u81f3\u5c11\u9700\u8981\u6709\u6700\u4f4e\u6c34\u5e73\u7684\u514d\u75ab\u80fd\u529b\u3002<\/p>\n

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\n\u7535\u8bdd\u4f1a\u8bae\u3001\u7f51\u7edc\u76f4\u64ad\u548c\u6f14\u793a\u5e7b\u706f\u7247<\/p>\n

\u7535\u8bdd\u4f1a\u8bae \u548c\u7f51\u7edc\u76f4\u64ad\u5c06\u4e8e\u5317\u4eac\u65f6\u95f42022\u5e7412\u670813\u65e5\u661f\u671f\u4e8c\u65e9\u66685\u70b930\u5206\u4e3e\u884c\uff08\u7f8e\u56fd\u4e1c\u90e8\u65f6\u95f4 2022 \u5e74 12 \u6708 12 \u65e5\u661f\u671f\u4e00\u4e0b\u5348 4:30 \u81f3 5:30 \uff09\uff0c\u4ee5\u63d0\u4f9b\u5728 ASH \u4f1a\u8bae\u4e0a\u5c55\u793a\u7684 CPI-818 \u6570\u636e\u7684\u6982\u8ff0\u3002\u53ef\u62e8\u62531-877-300-8521 \uff08\u7f8e\u56fd\u5883\u5185\u514d\u8d39\u7535\u8bdd\uff09\u62161-412-317-6026 \uff08\u56fd\u9645\uff09\u5e76\u4f7f\u7528\u4f1a\u8bae ID 10172958\u53c2\u52a0\u7535\u8bdd\u4f1a\u8bae\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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