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\n\u201c\u76ee\u524d\u8bfa\u8bda\u5065\u534e\u62e5\u6709\u4e00\u6b3e\u5546\u4e1a\u5316\u521b\u65b0\u836f\uff0c\u4ee5\u53ca\u4e5d\u6b3e\u4e34\u5e8a\u9636\u6bb5\u7684\u521b\u65b0\u836f\uff0c\u5176\u4e2d\u56db\u6b3e\u521b\u65b0\u836f\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u6fb3\u5927\u5229\u4e9a\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6211\u4eec\u5c06\u901a\u8fc7\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\u56e2\u961f\u7684\u65e0\u7f1d\u534f\u4f5c\uff0c\u7ee7\u7eed\u5728\u5168\u7403\u63a8\u8fdb\u5177\u6709\u5dee\u5f02\u5316\u7ade\u4e89\u529b\u7684\u521b\u65b0\u836f\u7269\u7ba1\u7ebf\u4e34\u5e8a\u8fdb\u5c55\uff0c\u540c\u65f6\u6211\u4eec\u4e5f\u5c06\u901a\u8fc7\u5185\u90e8\u7814\u53d1\u548c\u5916\u90e8\u5408\u4f5c\u8fdb\u4e00\u6b65\u52a0\u5f3a\u4ea7\u54c1\u7ba1\u7ebf\u3002\u201d<\/p>\n

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\n\u201c\u6211\u4eec\u5c06\u7ee7\u7eed\u805a\u7126\u6076\u6027\u80bf\u7624\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u5c1a\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u63a2\u7d22\u72ec\u7279\u7684\u5316\u5b66\u7ed3\u5408\u548c\u4f5c\u7528\u673a\u5236\uff0c\u5173\u6ce8\u836f\u7269\u9776\u70b9\u7684\u4ea4\u53c9\u751f\u7269\u5b66\u529f\u80fd\uff0c\u6253\u9020\u5177\u6709\u5dee\u5f02\u5316\u7279\u6027\u548c\u6f5c\u5728\u534f\u540c\u4f5c\u7528\u7684\u521b\u65b0\u836f\u7269\u3002\u201d<\/p>\n

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\n\u201c\u6211\u4eec\u901a\u8fc7\u5408\u4f5c\u5feb\u901f\u63a8\u51fa\u5927\u5206\u5b50\u836f\u7269\uff0c\u4e13\u6ce8\u4e8e\u8840\u6db2\u7624\u548c\u5b9e\u4f53\u7624\uff0c\u5e76\u4e0e\u5c0f\u5206\u5b50\u836f\u7269\u5f62\u6210\u534f\u540c\u6548\u5e94\u3002\u540c\u65f6\u6211\u4eec\u4e5f\u5728\u52a0\u5f3a\u5927\u5206\u5b50\u836f\u7269\u7814\u53d1\u80fd\u529b\uff0c\u5efa\u7acb\u4e86\u751f\u7269\u53d1\u73b0\u5e73\u53f0\u548c\u56e2\u961f\uff0c\u6db5\u76d6\u6297\u4f53\u53d1\u73b0\u3001\u86cb\u767d\u8d28\u79d1\u5b66\u548c\u5206\u5b50\u6d3b\u6027\u8bc4\u4ef7\u7b49\uff0c\u5e76\u5c06\u5efa\u8bbe\u5927\u5206\u5b50\u751f\u4ea7\u57fa\u5730\uff0c\u9010\u6b65\u5b8c\u5584\u4ece\u53d1\u73b0\u3001\u5f00\u53d1\u5230\u751f\u4ea7\u7684\u4e00\u4f53\u5316\u5927\u5206\u5b50\u836f\u7269\u5e73\u53f0\u3002\u201d<\/p>\n

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\n\u201c\u6211\u4eec\u5df2\u7ecf\u5efa\u7acb\u8d77\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u7684\u9ad8\u6548\u8f6c\u5316\u533b\u5b66\u7814\u7a76\u5e73\u53f0\uff0c\u6709\u6548\u4fc3\u8fdb\u5019\u9009\u836f\u7269\u4ece\u4e34\u5e8a\u524d\u5411\u4e34\u5e8a\u7814\u7a76\u7684\u8f6c\u5316\uff0c\u63d0\u9ad8\u836f\u7269\u7814\u53d1\u6548\u7387\u53ca\u6210\u529f\u7387\u3002\u76ee\u524d\uff0c\u516c\u53f8\u8d8a\u6765\u8d8a\u591a\u7684\u5c0f\u5206\u5b50\u548c\u5927\u5206\u5b50\u521b\u65b0\u836f\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\uff0c\u6211\u4eec\u6b63\u5229\u7528\u6211\u4eec\u7684\u5e73\u53f0\u52a0\u901f\u521b\u65b0\u836f\u6982\u5ff5\u9a8c\u8bc1\uff08POC\uff09\uff0c\u52a9\u63a8\u66f4\u591a\u521b\u65b0\u836f\u66f4\u5feb\u5730\u60e0\u53ca\u60a3\u8005\u3002\u201d<\/p>\n

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\n\u201c\u5728\u8840\u6db2\u7624\u9886\u57df\uff0c\u6211\u4eec\u5df2\u7ecf\u6784\u5efa\u4e86\u5f3a\u5927\u7684\u4ea7\u54c1\u7ba1\u7ebf\uff0c\u5305\u62ec\u6838\u5fc3\u4ea7\u54c1\u5965\u5e03\u66ff\u5c3c\u3001CD19\u6297\u4f53tafasitamab\uff0c\u4ee5\u53ca\u6db5\u76d6\u91cd\u8981\u8840\u6db2\u7624\u9776\u70b9\uff08\u4f8b\u5982BCL-2\u548cE3\u8fde\u63a5\u9176\uff09\u7b49\u591a\u79cd\u521b\u65b0\u836f\uff0c\u5c24\u5176\u5728\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u9886\u57df\uff0c\u6211\u4eec\u8fdb\u884c\u4e86\u5dee\u5f02\u5316\u5f00\u53d1\u7b56\u7565\uff0c\u6df1\u5ea6\u5e03\u5c40\u4ece\u4e00\u7ebf\u5230\u4e8c\u7ebf\u53ca\u4e8c\u7ebf\u53ca\u4ee5\u4e0a\u7684\u4e0d\u540c\u6cbb\u7597\u7b56\u7565\uff0c\u79ef\u6781\u63a2\u7d22\u4e0d\u540c\u673a\u5236\u7684\u8054\u5408\u7528\u836f\uff0c\u8bfa\u8bda\u5065\u534e\u81f4\u529b\u4e8e\u6210\u4e3a\u8840\u6db2\u7624\u9886\u57df\u7684\u9886\u5bfc\u8005\u3002\u201d<\/p>\n

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\n\u201c\u8bfa\u8bda\u5065\u534e\u6b63\u5728\u79ef\u6781\u5728\u5168\u7403\u63a8\u8fdb\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6bd4\u5982\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75aeII\u671f\u7814\u7a76\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002\u516c\u53f8\u8fd8\u6709\u4e24\u6b3e\u4ea7\u54c1ICP-332\u548cICP-488\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff0c\u8bfa\u8bda\u5065\u534e\u81f4\u529b\u4e8e\u4e3a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u9886\u57df\u672a\u88ab\u6ee1\u8db3\u7684\u5de8\u5927\u4e34\u5e8a\u9700\u6c42\u63d0\u4f9b\u53e3\u670d\u521b\u65b0\u836f\u3002\u5728\u5b9e\u4f53\u7624\u9886\u57df\uff0cFGFR\u6291\u5236\u5242Gunagratinib \uff08ICP-192\uff09\u548c\u6cdbTRK\u6291\u5236\u5242ICP-723\u5c06\u4e3a\u516c\u53f8\u5efa\u7acb\u575a\u5b9e\u7684\u5b9e\u4f53\u7624\u7ba1\u7ebf\u57fa\u7840\uff0c\u516c\u53f8\u4e5f\u5c06\u8fdb\u4e00\u6b65\u589e\u5f3a\u5728\u5b9e\u4f53\u7624\u9886\u57df\u7684\u7ba1\u7ebf\u5b9e\u529b\uff0c\u4e0d\u65ad\u63a8\u8fdb\u4e34\u5e8a\u5f00\u53d1\uff0c\u4e3a\u5b9e\u4f53\u7624\u60a3\u8005\u63d0\u4f9b\u6709\u7ade\u4e89\u529b\u7684\u89e3\u51b3\u65b9\u6848\u3002\u201d<\/p>\n

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\n\u201c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09\u4e34\u5e8a\u548c\u751f\u7269\u5b66\u884c\u4e3a\u4e0a\u5177\u6709\u9ad8\u5ea6\u5f02\u8d28\u6027\uff0c\u5982\u4f55\u5728\u5206\u5b50\u5c42\u9762\u8bc6\u522b\u5f02\u8d28\u6027\u5df2\u7ecf\u6210\u4e3a\u6307\u5bfcDLBCL\u7cbe\u51c6\u6cbb\u7597\u7684\u65b9\u5411\uff0c\u6cbb\u7597\u7406\u5ff5\u4e5f\u4e0d\u65ad\u6f14\u8fdb\u3002\u745e\u91d1\u533b\u9662\u4e0e\u8bfa\u8bda\u5065\u534e\u5408\u4f5c\u79ef\u6781\u63a8\u52a8\u57fa\u4e8e\u5206\u5b50\u5206\u578b\u7684R-CHOP+\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597DLBCL\u7684\u7814\u7a76\uff0c\u521d\u6b65\u7ed3\u679c\u5c55\u793a\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u4ee5\u53ca\u826f\u597d\u7684\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\uff0c\u5e76\u5df2\u88ab2022\u5e74ASCO\u63a5\u6536\u3002\u540c\u65f6\uff0c\u53cc\u65b9\u7ee7\u7eed\u5408\u4f5c\u542f\u52a8\u4e86R-CHOP+\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597DLBCL MCD\u4e9a\u578b\u60a3\u8005\u7684BELIEVE-01\u786e\u8bc1\u6027\u7814\u7a76\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u5c06\u6709\u671b\u4e3a\u8fd9\u4e00\u7c7b\u578b\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6f5c\u5728\u6cbb\u7597\u9009\u62e9\u3002\u201d<\/p>\n

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\n\u201c\u5728\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\u6cbb\u7597\u4e0a\u5b58\u5728\u5de8\u5927\u7684\u672a\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\uff0c\u76ee\u524d\u8fd8\u6ca1\u6709\u83b7\u6279\u7684\u53e3\u670d\u521b\u65b0\u836f\uff0c30%\u523050%\u7684SLE\u60a3\u8005\u5bf9\u6cbb\u7597\u6ca1\u6709\u53cd\u5e94\u3002\u5965\u5e03\u66ff\u5c3c\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\u53e3\u670d\u5965\u5e03\u66ff\u5c3c\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u826f\u597d\u3002\u5728\u6240\u6709\u63a5\u53d7\u6cbb\u7597\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u660e\u663e\u7684\u7597\u6548\u5448\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u8003\u8651\u5230\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u548c\u521b\u65b0\u6027\uff0c\u5965\u5e03\u66ff\u5c3c\u6709\u671b\u5f00\u53d1\u6210\u4e3a\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6f5c\u5728\u6cbb\u7597\u836f\u3002\u201d<\/p>\n

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